| 1 | Mon Nov 3 | vs Utah Tech | L79-81 (OT) | 0-1 | .000 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 2 | Wed Nov 5 | at #23Creighton | L76-92 | 0-2 | .000 | - | Peacock | CHI Health Center Omaha · Omaha, NE |
| 3 | Sun Nov 9 | vs TBD | W121-65 | 1-2 | .333 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 4 | Wed Nov 12 | vs So Indiana | W89-74 | 2-2 | .500 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 5 | Sun Nov 16 | vs W Michigan | W83-78 | 3-2 | .600 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 6 | Thu Nov 20 | at Missouri | L68-102 | 3-3 | .500 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 7 | Sun Nov 23 | vs SC State | W82-81 | 4-3 | .571 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 8 | Sat Nov 29 | vs Air Force | W80-63 | 5-3 | .625 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 9 | Wed Dec 3 | vs Portland St | L71-77 | 5-4 | .556 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 10 | Sat Dec 6 | at N Colorado | L87-89 (OT) | 5-5 | .500 | - | ESPN+ | Bank of Colorado Arena · Greeley, CO |
| 11 | Tue Dec 9 | at Wyoming | L79-106 | 5-6 | .455 | - | | Arena Auditorium · Laramie, WY |
| 12 | Sat Dec 13 | vs Prairie View | W97-85 | 6-6 | .500 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 13 | Wed Dec 17 | vs TBD | W80-71 | 7-6 | .538 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 14 | Sat Dec 20 | at Kansas St | L76-106 | 7-7 | .500 | - | ESPN+ | Bramlage Coliseum · Manhattan, KS |
| 15 | Sun Dec 28 | vs TBD | W85-61 | 8-7 | .533 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 16 | Wed Dec 31 | at N Dakota St | L61-84 | 8-8 | .500 | - | | Scheels Center · Fargo, ND |
| 17 | Wed Jan 7 | at St Thomas (MN) | L86-99 | 8-9 | .471 | - | | Schoenecker Arena · Saint Paul, MN |
| 18 | Sat Jan 10 | vs Denver | W82-72 | 9-9 | .500 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 19 | Thu Jan 15 | vs Kansas City | W99-83 | 10-9 | .526 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 20 | Sat Jan 17 | at North Dakota | L80-96 | 10-10 | .500 | - | | Betty Engelstad Sioux Center · Grand Forks, ND |
| 21 | Wed Jan 21 | at Omaha | W68-64 | 11-10 | .524 | - | | Baxter Arena · Omaha, NE |
| 22 | Sat Jan 24 | vs St Thomas (MN) | L78-90 | 11-11 | .500 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 23 | Thu Jan 29 | vs Oral Roberts | W77-69 | 12-11 | .522 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 24 | Sat Jan 31 | vs N Dakota St | L84-89 (OT) | 12-12 | .500 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 25 | Wed Feb 4 | at Kansas City | W82-75 (OT) | 13-12 | .520 | - | | Swinney Recreation Center · Kansas City, MO |
| 26 | Sat Feb 7 | at S Dakota St | W68-67 | 14-12 | .538 | - | CBSSN | Frost Arena · Brookings, SD |