| 1 | Mon Nov 3 | vs TBD | W99-75 | 1-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 2 | Sat Nov 8 | vs Fullerton | W92-82 | 2-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 3 | Tue Nov 11 | vs Austin Peay | W79-65 | 3-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 4 | Sat Nov 15 | vs Portland | W93-56 | 4-0 | 1.000 | - | | Arena Auditorium · Laramie, WY |
| 5 | Wed Nov 19 | at Sam Houston | L70-78 | 4-1 | .800 | - | ESPN+ | Bernard G. Johnson Coliseum · Huntsville, TX |
| 6 | Sun Nov 23 | vs Norfolk St | W75-67 | 5-1 | .833 | - | | Arena Auditorium · Laramie, WY |
| 7 | Wed Nov 26 | vs Denver | W101-59 | 6-1 | .857 | - | | Arena Auditorium · Laramie, WY |
| 8 | Sun Nov 30 | at #20Texas Tech | L72-76 | 6-2 | .750 | - | ESPN+ | United Supermarkets Arena · Lubbock, TX |
| 9 | Sat Dec 6 | vs Dartmouth | W93-80 | 7-2 | .778 | - | | Arena Auditorium · Laramie, WY |
| 10 | Tue Dec 9 | vs South Dakota | W106-79 | 8-2 | .800 | - | | Arena Auditorium · Laramie, WY |
| 11 | Mon Dec 15 | at S Dakota St | W87-72 | 9-2 | .818 | - | | Frost Arena · Brookings, SD |
| 12 | Sat Dec 20 | vs Grand Canyon | L70-82 | 9-3 | .750 | - | | Arena Auditorium · Laramie, WY |
| 13 | Tue Dec 30 | at Air Force | W68-56 | 10-3 | .769 | - | | Clune Arena · Colorado Springs, CO |
| 14 | Sat Jan 3 | at New Mexico | L58-78 | 10-4 | .714 | - | CBSSN | The Pit · Albuquerque, NM |
| 15 | Tue Jan 6 | vs UNLV | W98-66 | 11-4 | .733 | - | CBSSN | Arena Auditorium · Laramie, WY |
| 16 | Sat Jan 10 | at Nevada | L83-92 | 11-5 | .688 | - | | Lawlor Events Center · Reno, NV |
| 17 | Wed Jan 14 | vs SDSU | L57-74 | 11-6 | .647 | - | CBSSN | Arena Auditorium · Laramie, WY |
| 18 | Sat Jan 17 | at Fresno St | L60-63 | 11-7 | .611 | - | | Save Mart Center · Fresno, CA |
| 19 | Tue Jan 20 | vs Boise St | L65-81 | 11-8 | .579 | - | | Arena Auditorium · Laramie, WY |
| 20 | Sat Jan 24 | vs San Jose St | W66-62 | 12-8 | .600 | - | | Arena Auditorium · Laramie, WY |
| 21 | Wed Jan 28 | at Utah State | L62-94 | 12-9 | .571 | - | CBSSN | Dee Glen Smith Spectrum · Logan, UT |
| 22 | Sat Jan 31 | vs Colorado St | W68-57 | 13-9 | .591 | - | FS1 | Arena Auditorium · Laramie, WY |
| 23 | Tue Feb 3 | atSDSU | L63-72 | 13-10 | .565 | - | CBSSN | Viejas Arena · San Diego, CA |
| 24 | Sat Feb 7 | vsUtah State | L83-85 | 13-11 | .542 | - | CBSSN | Arena Auditorium · Laramie, WY |
