| 1 | Mon Nov 3 | vs TBD | W74-70 | 1-0 | 1.000 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 2 | Sat Nov 8 | at UC San Diego | L60-78 | 1-1 | .500 | - | ESPN+ | University Credit Union Center · Davis, CA |
| 3 | Thu Nov 13 | vs UL Monroe | W72-61 | 2-1 | .667 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 4 | Thu Nov 20 | vsTBD | W85-67 | 3-1 | .750 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 5 | Tue Nov 25 | at Bellarmine | L69-74 | 3-2 | .600 | - | | Knights Hall · Louisville, KY |
| 6 | Wed Nov 26 | at The Citadel | W72-65 | 4-2 | .667 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 7 | Sat Nov 29 | at Georgia So | L62-80 | 4-3 | .571 | - | ESPN+ | W.S. Hanner Fieldhouse · Statesboro, GA |
| 8 | Tue Dec 2 | at North Texas | L75-77 | 4-4 | .500 | - | ESPN+ | The Super Pit · Denton, TX |
| 9 | Sat Dec 6 | at New Orleans | W85-76 | 5-4 | .556 | - | ESPN+ | Lakefront Arena · New Orleans, LA |
| 10 | Sat Dec 13 | vs SE Louisiana | L71-74 (OT) | 5-5 | .500 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 11 | Mon Dec 15 | vs McNeese | L68-78 | 5-6 | .455 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 12 | Wed Dec 17 | at Nicholls | L64-79 | 5-7 | .417 | - | ESPN+ | David R. Stopher Gymnasium · Thibodaux, LA |
| 13 | Mon Dec 29 | at #3Iowa State | L61-89 | 5-8 | .385 | - | ESPN+ | James H. Hilton Coliseum · Ames, IA |
| 14 | Sat Jan 3 | at Incarnate Word | L56-73 | 5-9 | .357 | - | ESPN+ | Alice P. McDermott Convocation Center · San Antonio, TX |
| 15 | Mon Jan 5 | vs Texas A&M-CC | L65-81 | 5-10 | .333 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 16 | Sat Jan 10 | at SF Austin | L67-85 | 5-11 | .313 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 17 | Mon Jan 12 | at Lamar | L56-64 | 5-12 | .294 | - | ESPN+ | Montagne Center · Beaumont, TX |
| 18 | Sat Jan 17 | vs E Texas A&M | W81-70 | 6-12 | .333 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 19 | Mon Jan 19 | vs N'Western St | W82-80 | 7-12 | .368 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 20 | Sat Jan 24 | vs UT Rio Grande | L51-68 | 7-13 | .350 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 21 | Tue Jan 27 | vsIncarnate Word | W81-75 | 8-13 | .381 | - | ESPN+ | Sharp Gymnasium · Houston, TX |
| 22 | Sat Jan 31 | atTexas A&M-CC | L71-73 | 8-14 | .364 | - | ESPN+ | American Bank Center · Corpus Christi, TX |
| 23 | Mon Feb 2 | atUT Rio Grande | L57-74 | 8-15 | .348 | - | ESPN+ | UTRGV Fieldhouse · Edinburg, TX |
| 24 | Sat Feb 7 | atSE Louisiana | L47-55 | 8-16 | .333 | - | ESPN+ | University Center (LA) · Hammond, LA |
| 25 | Mon Feb 9 | atMcNeese | L69-73 | 8-17 | .320 | - | ESPN+ | Legacy Center · Lake Charles, LA |
