| 1 | Mon Nov 3 | vs TBD | W103-76 | 1-0 | 1.000 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 2 | Fri Nov 7 | vs Arkansas St | W90-65 | 2-0 | 1.000 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 3 | Tue Nov 11 | at Rice | W81-69 | 3-0 | 1.000 | - | ESPN+ | Tudor Fieldhouse · Houston, TX |
| 4 | Fri Nov 14 | vs Abilene Chrstn | W76-66 | 4-0 | 1.000 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 5 | Tue Nov 18 | at Fresno St | L78-80 | 4-1 | .800 | - | | Save Mart Center · Fresno, CA |
| 6 | Fri Nov 21 | at Pepperdine | W63-60 | 5-1 | .833 | - | ESPN+ | Firestone Fieldhouse · Malibu, CA |
| 7 | Sat Nov 29 | at UT Arlington | L61-66 | 5-2 | .714 | - | ESPN+ | College Park Center · Arlington, TX |
| 8 | Wed Dec 3 | vs UT Rio Grande | W73-60 | 6-2 | .750 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 9 | Sun Dec 7 | vs UL Monroe | W96-76 | 7-2 | .778 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 10 | Wed Dec 17 | vs Texas A&M-CC | W69-60 | 8-2 | .800 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 11 | Sun Dec 21 | vsTBD | W103-55 | 9-2 | .818 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 12 | Mon Dec 29 | at E Texas A&M | W75-48 | 10-2 | .833 | - | ESPN+ | The Field House · Commerce, TX |
| 13 | Wed Dec 31 | at N'Western St | W74-64 | 11-2 | .846 | - | ESPN+ | Prather Coliseum · Natchitoches, LA |
| 14 | Sat Jan 3 | at SE Louisiana | W73-63 | 12-2 | .857 | - | ESPN+ | University Center (LA) · Hammond, LA |
| 15 | Mon Jan 5 | at McNeese | L64-66 | 12-3 | .800 | - | ESPN+ | Legacy Center · Lake Charles, LA |
| 16 | Sat Jan 10 | vs Hou Christian | W85-67 | 13-3 | .813 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 17 | Mon Jan 12 | vs Incarnate Word | W56-46 | 14-3 | .824 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 18 | Sat Jan 17 | at New Orleans | W84-79 | 15-3 | .833 | - | ESPN+ | Lakefront Arena · New Orleans, LA |
| 19 | Mon Jan 19 | at Nicholls | W79-62 | 16-3 | .842 | - | ESPN+ | David R. Stopher Gymnasium · Thibodaux, LA |
| 20 | Sat Jan 24 | at Lamar | W88-81 | 17-3 | .850 | - | ESPN+ | Montagne Center · Beaumont, TX |
| 21 | Tue Jan 27 | vsN'Western St | W69-67 | 18-3 | .857 | - | CBSSN | William R. Johnson Coliseum · Nacogdoches, TX |
| 22 | Sat Jan 31 | vsSE Louisiana | W85-58 | 19-3 | .864 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 23 | Mon Feb 2 | vsMcNeese | W67-60 | 20-3 | .870 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 24 | Sat Feb 7 | vsLamar | W84-74 | 21-3 | .875 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
| 25 | Mon Feb 9 | vsE Texas A&M | W74-70 | 22-3 | .880 | - | ESPN+ | William R. Johnson Coliseum · Nacogdoches, TX |
