| 1 | Mon Nov 3 | at Virginia Tech | L67-98 | 0-1 | .000 | - | ACC Extra | Cassell Coliseum · Blacksburg, VA |
| 2 | Thu Nov 6 | vs TBD | W106-71 | 1-1 | .500 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 3 | Mon Nov 10 | at The Citadel | W96-86 | 2-1 | .667 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 4 | Thu Nov 13 | at Alabama A&M | L64-68 | 2-2 | .500 | - | | T.M. Elmore Gymnasium · Normal, AL |
| 5 | Fri Nov 14 | vs Lindenwood | L77-83 | 2-3 | .400 | - | | Buccaneer Fieldhouse · Charleston, SC |
| 6 | Tue Nov 18 | vs IU Indy | W103-91 | 3-3 | .500 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 7 | Fri Nov 21 | at E Carolina | W77-65 | 4-3 | .571 | - | ESPN+ | Williams Arena at Minges Coliseum · Greenville, NC |
| 8 | Tue Nov 25 | vsTBD | W93-81 | 5-3 | .625 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 9 | Fri Nov 28 | at South Carolina | L62-74 | 5-4 | .556 | - | SECN+ | Colonial Life Arena · Columbia, SC |
| 10 | Tue Dec 2 | at UT Martin | L56-73 | 5-5 | .500 | - | ESPN+ | Kathleen and Tom Elam Center · Martin, TN |
| 11 | Thu Dec 4 | vsTBD | W124-63 | 6-5 | .545 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 12 | Mon Dec 8 | vs SC State | W84-44 | 7-5 | .583 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 13 | Thu Dec 18 | vs North Florida | W113-90 | 8-5 | .615 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 14 | Sun Dec 21 | at Furman | L76-84 | 8-6 | .571 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 15 | Sun Dec 28 | at Richmond | W77-72 | 9-6 | .600 | - | ESPN+ | Robins Center · Richmond, VA |
| 16 | Wed Dec 31 | at Gardner-Webb | W89-79 | 10-6 | .625 | - | ESPN+ | Paul Porter Arena · Boiling Springs, NC |
| 17 | Sat Jan 3 | vs UNC Asheville | W86-83 | 11-6 | .647 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 18 | Wed Jan 7 | at Winthrop | L77-81 | 11-7 | .611 | - | ESPN+ | Winthrop Coliseum · Rock Hill, SC |
| 19 | Sat Jan 10 | vs High Point | L82-84 (OT) | 11-8 | .579 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 20 | Wed Jan 14 | vs SC Upstate | L81-86 (OT) | 11-9 | .550 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 21 | Wed Jan 21 | at Presbyterian | L83-87 | 11-10 | .524 | - | ESPN+ | Ross E. Templeton P.E. Center · Clinton, SC |
| 22 | Fri Jan 23 | at Longwood | L79-81 (OT) | 11-11 | .500 | - | ESPN+ | Willett Hall · Farmville, VA |
| 23 | Thu Jan 29 | vs Radford | L75-84 | 11-12 | .478 | - | ESPN+ | Buccaneer Fieldhouse · Charleston, SC |
| 24 | Wed Feb 4 | atHigh Point | L55-80 | 11-13 | .458 | - | ESPN+ | Nido and Mariana Qubein Arena · High Point, NC |
| 25 | Sat Feb 7 | atSC Upstate | L94-100 (OT) | 11-14 | .440 | - | ESPN+ | G.B. Hodge Center · Spartanburg, SC |
