| 1 | Mon Nov 3 | vs TBD | W122-58 | 1-0 | 1.000 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 2 | Fri Nov 7 | at So Indiana | W78-74 | 2-0 | 1.000 | - | ESPN+ | Screaming Eagles Arena · Evansville, IN |
| 3 | Sun Nov 9 | at Missouri | L68-106 | 2-1 | .667 | - | SEC Network | Mizzou Arena · Columbia, MO |
| 4 | Wed Nov 12 | vsTBD | W106-54 | 3-1 | .750 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 5 | Sat Nov 15 | vs Jacksonville | L67-69 | 3-2 | .600 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 6 | Wed Nov 19 | at Richmond | L54-87 | 3-3 | .500 | - | ESPN+ | Robins Center · Richmond, VA |
| 7 | Sat Nov 22 | at Stetson | L80-99 | 3-4 | .429 | - | ESPN+ | Edmunds Center · Deland, FL |
| 8 | Mon Nov 24 | at Buffalo | L70-78 | 3-5 | .375 | - | | Alumni Arena · Buffalo, NY |
| 9 | Wed Nov 26 | vs Bowling Green | L48-81 | 3-6 | .333 | - | | Cameron Hall · Lexington, VA |
| 10 | Sat Nov 29 | at UCF | L57-82 | 3-7 | .300 | - | ESPN+ | Addition Financial Arena · Orlando, FL |
| 11 | Fri Dec 5 | vsTBD | W89-36 | 4-7 | .364 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 12 | Tue Dec 9 | vs Loyola MD | W86-70 | 5-7 | .417 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 13 | Sun Dec 21 | at Radford | L90-97 | 5-8 | .385 | - | ESPN+ | Donald N. Dedmon Center · Radford, VA |
| 14 | Thu Jan 1 | vs Samford | L58-78 | 5-9 | .357 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 15 | Sat Jan 3 | vs Chattanooga | W79-71 | 6-9 | .400 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 16 | Wed Jan 7 | at ETSU | L67-81 | 6-10 | .375 | - | ESPN+ | Freedom Hall Civic Center · Johnson City, TN |
| 17 | Sat Jan 10 | at Furman | L48-69 | 6-11 | .353 | - | ESPN+ | Timmons Arena · Greenville, SC |
| 18 | Thu Jan 15 | vs Mercer | L67-77 | 6-12 | .333 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 19 | Sat Jan 17 | vs The Citadel | L68-82 | 6-13 | .316 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 20 | Wed Jan 21 | vs UNC Greensboro | L78-85 | 6-14 | .300 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 21 | Sat Jan 24 | at W Carolina | L58-88 | 6-15 | .286 | - | ESPN+ | Ramsey Regional Activity Center · Cullowhee, NC |
| 22 | Thu Jan 29 | atThe Citadel | L56-80 | 6-16 | .273 | - | ESPN+ | McAlister Field House · Charleston, SC |
| 23 | Sat Jan 31 | atMercer | L81-95 | 6-17 | .261 | - | ESPN+ | Hawkins Arena · Macon, GA |
| 24 | Wed Feb 4 | vs Wofford | L67-81 | 6-18 | .250 | - | ESPN+ | Cameron Hall · Lexington, VA |
| 25 | Sat Feb 7 | vsETSU | L70-87 | 6-19 | .240 | - | ESPN+ | Cameron Hall · Lexington, VA |
