| 1 | Sat Oct 16 | at Avalanche | W5-3 | 1-0-0 | 2 PTS | Ball Arena · Denver, CO |
| 2 | Mon Oct 18 | at Coyotes | W7-4 | 2-0-0 | 4 PTS | Mullett Arena · Tempe, AZ |
| 3 | Wed Oct 20 | at Knights | W3-1 | 3-0-0 | 6 PTS | T-Mobile Arena · Las Vegas, NV |
| 4 | Sat Oct 23 | vs Kings | W7-3 | 4-0-0 | 8 PTS | Enterprise Center · St. Louis, MO |
| 5 | Mon Oct 25 | vsKings | W3-0 | 5-0-0 | 10 PTS | Enterprise Center · St. Louis, MO |
| 6 | Thu Oct 28 | vsAvalanche | L3-4 | 5-1-0 | 10 PTS | Enterprise Center · St. Louis, MO |
| 7 | Sat Oct 30 | vs Blackhawks | W1-0 | 6-1-0 | 12 PTS | Enterprise Center · St. Louis, MO |
| 8 | Wed Nov 3 | atKings | L2-3 (SO) | 6-1-1 | 13 PTS | Crypto.com Arena · Los Angeles, CA |
| 9 | Thu Nov 4 | at Sharks | W5-3 | 7-1-1 | 15 PTS | SAP Center · San Jose, CA |
| 10 | Sun Nov 7 | at Ducks | L1-4 | 7-2-1 | 15 PTS | Honda Center · Anaheim, CA |
| 11 | Tue Nov 9 | at Jets | W3-2 (SO) | 8-2-1 | 17 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 12 | Thu Nov 11 | vs Predators | L3-4 (OT) | 8-2-2 | 18 PTS | Enterprise Center · St. Louis, MO |
| 13 | Sat Nov 13 | at Hurricanes | L2-3 | 8-3-2 | 18 PTS | PNC Arena · Raleigh, NC |
| 14 | Sun Nov 14 | vs Oilers | L4-5 | 8-4-2 | 18 PTS | Enterprise Center · St. Louis, MO |
| 15 | Tue Nov 16 | vsCoyotes | L2-3 | 8-5-2 | 18 PTS | Enterprise Center · St. Louis, MO |
| 16 | Thu Nov 18 | vsSharks | W4-1 | 9-5-2 | 20 PTS | Enterprise Center · St. Louis, MO |
| 17 | Sat Nov 20 | at Stars | L1-4 | 9-6-2 | 20 PTS | American Airlines Center · Dallas, TX |
| 18 | Mon Nov 22 | vsKnights | W5-2 | 10-6-2 | 22 PTS | Enterprise Center · St. Louis, MO |
| 19 | Wed Nov 24 | at Red Wings | L2-4 | 10-7-2 | 22 PTS | Little Caesars Arena · Detroit, MI |
| 20 | Fri Nov 26 | atBlackhawks | L2-3 (OT) | 10-7-3 | 23 PTS | United Center · Chicago, IL |
| 21 | Sat Nov 27 | vs Jackets | W6-3 | 11-7-3 | 25 PTS | Enterprise Center · St. Louis, MO |
| 22 | Tue Nov 30 | vs Lightning | W4-3 (SO) | 12-7-3 | 27 PTS | Enterprise Center · St. Louis, MO |
| 23 | Thu Dec 2 | atLightning | L2-4 | 12-8-3 | 27 PTS | AMALIE Arena · Tampa, FL |
| 24 | Sat Dec 4 | at Panthers | L3-4 (SO) | 12-8-4 | 28 PTS | Amerant Bank Arena · Sunrise, FL |
| 25 | Tue Dec 7 | vsPanthers | W4-3 (OT) | 13-8-4 | 30 PTS | Enterprise Center · St. Louis, MO |
| 26 | Thu Dec 9 | vsRed Wings | W6-2 | 14-8-4 | 32 PTS | Enterprise Center · St. Louis, MO |
| 27 | Sat Dec 11 | vs Canadiens | W4-1 | 15-8-4 | 34 PTS | Enterprise Center · St. Louis, MO |
| 28 | Sun Dec 12 | vsDucks | L2-3 (OT) | 15-8-5 | 35 PTS | Enterprise Center · St. Louis, MO |
| 29 | Tue Dec 14 | atStars | W4-1 | 16-8-5 | 37 PTS | American Airlines Center · Dallas, TX |
| 30 | Fri Dec 17 | vsStars | W4-1 | 17-8-5 | 39 PTS | Enterprise Center · St. Louis, MO |
| 31 | Sun Dec 19 | atJets | L2-4 | 17-9-5 | 39 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 32 | Wed Dec 29 | vsOilers | W4-2 | 18-9-5 | 41 PTS | Enterprise Center · St. Louis, MO |
| 33 | Sat Jan 1 | at Wild | W6-4 | 19-9-5 | 43 PTS | Xcel Energy Center · St. Paul, MN |
| 34 | Wed Jan 5 | at Penguins | L3-5 | 19-10-5 | 43 PTS | PPG Paints Arena · Pittsburgh, PA |
| 35 | Fri Jan 7 | vs Capitals | W5-1 | 20-10-5 | 45 PTS | Enterprise Center · St. Louis, MO |
| 36 | Sun Jan 9 | vsStars | W2-1 | 21-10-5 | 47 PTS | Enterprise Center · St. Louis, MO |
| 37 | Thu Jan 13 | vs Kraken | W2-1 | 22-10-5 | 49 PTS | Enterprise Center · St. Louis, MO |
| 38 | Sat Jan 15 | vs Maple Leafs | L5-6 | 22-11-5 | 49 PTS | Enterprise Center · St. Louis, MO |
| 39 | Mon Jan 17 | vsPredators | W5-3 | 23-11-5 | 51 PTS | Enterprise Center · St. Louis, MO |
| 40 | Fri Jan 21 | atKraken | W5-0 | 24-11-5 | 53 PTS | Climate Pledge Arena · Seattle, WA |
| 41 | Sun Jan 23 | at Canucks | W3-1 | 25-11-5 | 55 PTS | Rogers Arena · Vancouver, British Columbia |
| 42 | Mon Jan 24 | at Flames | L1-7 | 25-12-5 | 55 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 43 | Thu Jan 27 | vsFlames | W5-1 | 26-12-5 | 57 PTS | Enterprise Center · St. Louis, MO |
| 44 | Sat Jan 29 | vsJets | L1-4 | 26-13-5 | 57 PTS | Enterprise Center · St. Louis, MO |
| 45 | Thu Feb 10 | vs Devils | L4-7 | 26-14-5 | 57 PTS | Enterprise Center · St. Louis, MO |
| 46 | Sat Feb 12 | vsBlackhawks | W5-1 | 27-14-5 | 59 PTS | Enterprise Center · St. Louis, MO |
| 47 | Tue Feb 15 | at Senators | W5-2 | 28-14-5 | 61 PTS | Canadian Tire Centre · Ottawa, ON |
| 48 | Thu Feb 17 | atCanadiens | L2-3 (OT) | 28-14-6 | 62 PTS | Bell Centre · Montreal, QC |
| 49 | Sat Feb 19 | atMaple Leafs | W6-3 | 29-14-6 | 64 PTS | Scotiabank Arena · Toronto, ON |
| 50 | Tue Feb 22 | at Flyers | W4-1 | 30-14-6 | 66 PTS | Wells Fargo Center · Philadelphia, PA |
| 51 | Fri Feb 25 | vs Sabres | W5-3 | 31-14-6 | 68 PTS | Enterprise Center · St. Louis, MO |
| 52 | Sun Feb 27 | atBlackhawks | W4-0 | 32-14-6 | 70 PTS | United Center · Chicago, IL |
| 53 | Wed Mar 2 | at Rangers | L3-5 | 32-15-6 | 70 PTS | Madison Square Garden · Manhattan, NY |
| 54 | Sat Mar 5 | at Islanders | L1-2 | 32-16-6 | 70 PTS | UBS Arena · Elmont, NY |
| 55 | Sun Mar 6 | atDevils | L2-3 (OT) | 32-16-7 | 71 PTS | Prudential Center · Newark, NJ |
| 56 | Tue Mar 8 | vsSenators | L1-4 | 32-17-7 | 71 PTS | Enterprise Center · St. Louis, MO |
| 57 | Thu Mar 10 | vsRangers | W6-2 | 33-17-7 | 73 PTS | Enterprise Center · St. Louis, MO |
| 58 | Sat Mar 12 | atPredators | W7-4 | 34-17-7 | 75 PTS | Bridgestone Arena · Nashville, TN |
| 59 | Sun Mar 13 | vsJets | L3-4 (OT) | 34-17-8 | 76 PTS | Enterprise Center · St. Louis, MO |
| 60 | Thu Mar 17 | vsPenguins | L2-3 (SO) | 34-17-9 | 77 PTS | Enterprise Center · St. Louis, MO |
| 61 | Sat Mar 19 | atJackets | L4-5 | 34-18-9 | 77 PTS | Nationwide Arena · Columbus, OH |
| 62 | Tue Mar 22 | atCapitals | W5-2 | 35-18-9 | 79 PTS | Capital One Arena · Washington, D.C. |
| 63 | Thu Mar 24 | vsFlyers | L2-5 | 35-19-9 | 79 PTS | Enterprise Center · St. Louis, MO |
| 64 | Sat Mar 26 | vsHurricanes | L2-7 | 35-20-9 | 79 PTS | Enterprise Center · St. Louis, MO |
| 65 | Mon Mar 28 | vsCanucks | W4-1 | 36-20-9 | 81 PTS | Enterprise Center · St. Louis, MO |
| 66 | Wed Mar 30 | atCanucks | W4-3 | 37-20-9 | 83 PTS | Rogers Arena · Vancouver, British Columbia |
| 67 | Fri Apr 1 | atOilers | L5-6 (OT) | 37-20-10 | 84 PTS | Rogers Place · Edmonton, AB |
| 68 | Sat Apr 2 | atFlames | W6-4 | 38-20-10 | 86 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 69 | Mon Apr 4 | vsCoyotes | W5-1 | 39-20-10 | 88 PTS | Enterprise Center · St. Louis, MO |
| 70 | Wed Apr 6 | vsKraken | W4-1 | 40-20-10 | 90 PTS | Enterprise Center · St. Louis, MO |
| 71 | Fri Apr 8 | vsWild | W4-3 (OT) | 41-20-10 | 92 PTS | Enterprise Center · St. Louis, MO |
| 72 | Sat Apr 9 | vsIslanders | W6-1 | 42-20-10 | 94 PTS | Enterprise Center · St. Louis, MO |
| 73 | Tue Apr 12 | at Bruins | W4-2 | 43-20-10 | 96 PTS | TD Garden · Boston, MA |
| 74 | Thu Apr 14 | atSabres | W6-2 | 44-20-10 | 98 PTS | KeyBank Center · Buffalo, NY |
| 75 | Sat Apr 16 | vsWild | W6-5 (OT) | 45-20-10 | 100 PTS | Enterprise Center · St. Louis, MO |
| 76 | Sun Apr 17 | atPredators | W8-3 | 46-20-10 | 102 PTS | Bridgestone Arena · Nashville, TN |
| 77 | Tue Apr 19 | vsBruins | L2-3 (OT) | 46-20-11 | 103 PTS | Enterprise Center · St. Louis, MO |
| 78 | Thu Apr 21 | atSharks | W3-1 | 47-20-11 | 105 PTS | SAP Center · San Jose, CA |
| 79 | Sat Apr 23 | atCoyotes | W5-4 (OT) | 48-20-11 | 107 PTS | Mullett Arena · Tempe, AZ |
| 80 | Sun Apr 24 | atDucks | W6-3 | 49-20-11 | 109 PTS | Honda Center · Anaheim, CA |
| 81 | Tue Apr 26 | atAvalanche | L3-5 | 49-21-11 | 109 PTS | Ball Arena · Denver, CO |
| 82 | Fri Apr 29 | vsKnights | L4-7 | 49-22-11 | 109 PTS | Enterprise Center · St. Louis, MO |
| 1 | Mon May 2 | atWild | W4-0 | 1-0 | 1.000 | Xcel Energy Center · St. Paul, MN |
| 2 | Wed May 4 | atWild | L2-6 | 1-1 | .500 | Xcel Energy Center · St. Paul, MN |
| 3 | Fri May 6 | vsWild | L1-5 | 1-2 | .333 | Enterprise Center · St. Louis, MO |
| 4 | Sun May 8 | vsWild | W5-2 | 2-2 | .500 | Enterprise Center · St. Louis, MO |
| 5 | Tue May 10 | atWild | W5-2 | 3-2 | .600 | Xcel Energy Center · St. Paul, MN |
| 6 | Thu May 12 | vsWild | W5-1 | 4-2 | .667 | Enterprise Center · St. Louis, MO |
| 1 | Tue May 17 | atAvalanche | L2-3 (OT) | 0-1 | .000 | Ball Arena · Denver, CO |
| 2 | Thu May 19 | atAvalanche | W4-1 | 1-1 | .500 | Ball Arena · Denver, CO |
| 3 | Sat May 21 | vsAvalanche | L2-5 | 1-2 | .333 | Enterprise Center · St. Louis, MO |
| 4 | Mon May 23 | vsAvalanche | L3-6 | 1-3 | .250 | Enterprise Center · St. Louis, MO |
| 5 | Wed May 25 | atAvalanche | W5-4 (OT) | 2-3 | .400 | Ball Arena · Denver, CO |
| 6 | Fri May 27 | vsAvalanche | L2-3 | 2-4 | .333 | Enterprise Center · St. Louis, MO |
