| 1 | Thu Oct 9 | at Panthers | L1-2 | 0-1-0 | 0 PTS | Amerant Bank Arena · Sunrise, FL |
| 2 | Sat Oct 11 | at Hurricanes | L3-4 (OT) | 0-1-1 | 1 PTS | PNC Arena · Raleigh, NC |
| 3 | Mon Oct 13 | vsPanthers | W5-2 | 1-1-1 | 3 PTS | Wells Fargo Center · Philadelphia, PA |
| 4 | Thu Oct 16 | vs Jets | L2-5 | 1-2-1 | 3 PTS | Wells Fargo Center · Philadelphia, PA |
| 5 | Sat Oct 18 | vs Wild | W2-1 (OT) | 2-2-1 | 5 PTS | Wells Fargo Center · Philadelphia, PA |
| 6 | Mon Oct 20 | vs Kraken | W5-2 | 3-2-1 | 7 PTS | Wells Fargo Center · Philadelphia, PA |
| 7 | Thu Oct 23 | at Senators | L1-2 | 3-3-1 | 7 PTS | Canadian Tire Centre · Ottawa, ON |
| 8 | Sat Oct 25 | vs Islanders | W4-3 (SO) | 4-3-1 | 9 PTS | Wells Fargo Center · Philadelphia, PA |
| 9 | Tue Oct 28 | vs Penguins | W3-2 (SO) | 5-3-1 | 11 PTS | Wells Fargo Center · Philadelphia, PA |
| 10 | Thu Oct 30 | vs Predators | W4-1 | 6-3-1 | 13 PTS | Wells Fargo Center · Philadelphia, PA |
| 11 | Sat Nov 1 | vs Maple Leafs | L2-5 | 6-4-1 | 13 PTS | Wells Fargo Center · Philadelphia, PA |
| 12 | Sun Nov 2 | vs Flames | L1-2 | 6-5-1 | 13 PTS | Wells Fargo Center · Philadelphia, PA |
| 13 | Tue Nov 4 | at Canadiens | W5-4 (SO) | 7-5-1 | 15 PTS | Bell Centre · Montreal, QC |
| 14 | Thu Nov 6 | atPredators | W3-1 | 8-5-1 | 17 PTS | Bridgestone Arena · Nashville, TN |
| 15 | Sat Nov 8 | vsSenators | L2-3 (OT) | 8-5-2 | 18 PTS | Wells Fargo Center · Philadelphia, PA |
| 16 | Wed Nov 12 | vs Oilers | L1-2 (OT) | 8-5-3 | 19 PTS | Wells Fargo Center · Philadelphia, PA |
| 17 | Fri Nov 14 | at Blues | W6-5 (SO) | 9-5-3 | 21 PTS | Enterprise Center · St. Louis, MO |
| 18 | Sat Nov 15 | at Stars | L1-5 | 9-6-3 | 21 PTS | American Airlines Center · Dallas, TX |
| 19 | Thu Nov 20 | vsBlues | W3-2 (OT) | 10-6-3 | 23 PTS | Wells Fargo Center · Philadelphia, PA |
| 20 | Sat Nov 22 | vs Devils | W6-3 | 11-6-3 | 25 PTS | Wells Fargo Center · Philadelphia, PA |
| 21 | Mon Nov 24 | at Lightning | L0-3 | 11-7-3 | 25 PTS | Benchmark International Arena · Tampa, FL |
| 22 | Wed Nov 26 | atPanthers | W4-2 | 12-7-3 | 27 PTS | Amerant Bank Arena · Sunrise, FL |
| 23 | Fri Nov 28 | atIslanders | W4-3 (SO) | 13-7-3 | 29 PTS | UBS Arena · Elmont, NY |
| 24 | Sat Nov 29 | atDevils | W5-3 | 14-7-3 | 31 PTS | Prudential Center · Newark, NJ |
| 25 | Mon Dec 1 | vsPenguins | L1-5 | 14-8-3 | 31 PTS | Wells Fargo Center · Philadelphia, PA |
| 26 | Wed Dec 3 | vs Sabres | W5-2 | 15-8-3 | 33 PTS | Wells Fargo Center · Philadelphia, PA |
| 27 | Sun Dec 7 | vs Avalanche | L2-3 | 15-9-3 | 33 PTS | Wells Fargo Center · Philadelphia, PA |
| 28 | Tue Dec 9 | vs Sharks | W4-1 | 16-9-3 | 35 PTS | Wells Fargo Center · Philadelphia, PA |
| 29 | Thu Dec 11 | vs Knights | L2-3 (OT) | 16-9-4 | 36 PTS | Wells Fargo Center · Philadelphia, PA |
| 30 | Sat Dec 13 | vsHurricanes | L3-4 (SO) | 16-9-5 | 37 PTS | Wells Fargo Center · Philadelphia, PA |
| 31 | Sun Dec 14 | atHurricanes | L2-3 (SO) | 16-9-6 | 38 PTS | PNC Arena · Raleigh, NC |
| 32 | Tue Dec 16 | atCanadiens | W4-1 | 17-9-6 | 40 PTS | Bell Centre · Montreal, QC |
| 33 | Thu Dec 18 | atSabres | L3-5 | 17-10-6 | 40 PTS | KeyBank Center · Buffalo, NY |
| 34 | Sat Dec 20 | at Rangers | L4-5 (SO) | 17-10-7 | 41 PTS | Madison Square Garden · Manhattan, NY |
| 35 | Mon Dec 22 | vs Canucks | W5-2 | 18-10-7 | 43 PTS | Wells Fargo Center · Philadelphia, PA |
| 36 | Tue Dec 23 | at Blackhawks | W3-1 | 19-10-7 | 45 PTS | United Center · Chicago, IL |
| 37 | Sun Dec 28 | atKraken | L1-4 | 19-11-7 | 45 PTS | Climate Pledge Arena · Seattle, WA |
| 38 | Tue Dec 30 | atCanucks | W6-3 | 20-11-7 | 47 PTS | Rogers Arena · Vancouver, British Columbia |
| 39 | Wed Dec 31 | atFlames | L1-5 | 20-12-7 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 40 | Sat Jan 3 | atOilers | W5-2 | 21-12-7 | 49 PTS | Rogers Place · Edmonton, AB |
| 41 | Tue Jan 6 | vs Ducks | W5-2 | 22-12-7 | 51 PTS | Wells Fargo Center · Philadelphia, PA |
| 42 | Thu Jan 8 | vsMaple Leafs | L1-2 (OT) | 22-12-8 | 52 PTS | Wells Fargo Center · Philadelphia, PA |
| 43 | Sat Jan 10 | vsLightning | L2-7 | 22-13-8 | 52 PTS | Wells Fargo Center · Philadelphia, PA |
| 44 | Mon Jan 12 | vsLightning | L1-5 | 22-14-8 | 52 PTS | Wells Fargo Center · Philadelphia, PA |
| 45 | Wed Jan 14 | atSabres | L2-5 | 22-15-8 | 52 PTS | KeyBank Center · Buffalo, NY |
| 46 | Thu Jan 15 | atPenguins | L3-6 | 22-16-8 | 52 PTS | PPG Paints Arena · Pittsburgh, PA |
| 47 | Sat Jan 17 | vsRangers | L3-6 | 22-17-8 | 52 PTS | Wells Fargo Center · Philadelphia, PA |
| 48 | Mon Jan 19 | atKnights | W2-1 | 23-17-8 | 54 PTS | T-Mobile Arena · Las Vegas, NV |
| 49 | Wed Jan 21 | at Mammoth | L4-5 (OT) | 23-17-9 | 55 PTS | Delta Center · Salt Lake City, UT |
| 50 | Fri Jan 23 | atAvalanche | W7-3 | 24-17-9 | 57 PTS | Ball Arena · Denver, CO |
| 51 | Mon Jan 26 | vsIslanders | L0-4 | 24-18-9 | 57 PTS | Wells Fargo Center · Philadelphia, PA |
| 52 | Wed Jan 28 | at Jackets | L3-5 | 24-19-9 | 57 PTS | Nationwide Arena · Columbus, OH |
| 53 | Thu Jan 29 | at Bruins | L3-6 | 24-20-9 | 57 PTS | TD Garden · Boston, MA |
| 54 | Sat Jan 31 | vs Kings | L2-3 (OT) | 24-20-10 | 58 PTS | Wells Fargo Center · Philadelphia, PA |
| 55 | Tue Feb 3 | vs Capitals | W4-2 | 25-20-10 | 60 PTS | Wells Fargo Center · Philadelphia, PA |
| 56 | Thu Feb 5 | vsSenators | L1-2 (OT) | 25-20-11 | 61 PTS | Wells Fargo Center · Philadelphia, PA |
Red Wings