| 1 | Wed Oct 8 | at Oilers | W4-3 (SO) | 1-0-0 | 2 PTS | Rogers Place · Edmonton, AB |
| 2 | Thu Oct 9 | at Canucks | L1-5 | 1-1-0 | 2 PTS | Rogers Arena · Vancouver, British Columbia |
| 3 | Sat Oct 11 | vs Blues | L2-4 | 1-2-0 | 2 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 4 | Tue Oct 14 | vs Knights | L2-4 | 1-3-0 | 2 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 5 | Wed Oct 15 | at Mammoth | L1-3 | 1-4-0 | 2 PTS | Delta Center · Salt Lake City, UT |
| 6 | Sat Oct 18 | atKnights | L1-6 | 1-5-0 | 2 PTS | T-Mobile Arena · Las Vegas, NV |
| 7 | Mon Oct 20 | vs Jets | L1-2 | 1-6-0 | 2 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 8 | Wed Oct 22 | vs Canadiens | L1-2 (OT) | 1-6-1 | 3 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 9 | Fri Oct 24 | atJets | L3-5 | 1-7-1 | 3 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 10 | Sun Oct 26 | vs Rangers | W5-1 | 2-7-1 | 5 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 11 | Tue Oct 28 | at Maple Leafs | L3-4 | 2-8-1 | 5 PTS | Scotiabank Arena · Toronto, ON |
| 12 | Thu Oct 30 | at Senators | L3-4 (SO) | 2-8-2 | 6 PTS | Canadian Tire Centre · Ottawa, ON |
| 13 | Sat Nov 1 | at Predators | L2-4 | 2-9-2 | 6 PTS | Bridgestone Arena · Nashville, TN |
| 14 | Sun Nov 2 | at Flyers | W2-1 | 3-9-2 | 8 PTS | Wells Fargo Center · Philadelphia, PA |
| 15 | Wed Nov 5 | vs Jackets | W5-1 | 4-9-2 | 10 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 16 | Fri Nov 7 | vs Blackhawks | L0-4 | 4-10-2 | 10 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 17 | Sun Nov 9 | at Wild | L0-2 | 4-11-2 | 10 PTS | Xcel Energy Center · St. Paul, MN |
| 18 | Tue Nov 11 | atBlues | L2-3 | 4-12-2 | 10 PTS | Enterprise Center · St. Louis, MO |
| 19 | Thu Nov 13 | vs Sharks | W2-0 | 5-12-2 | 12 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 20 | Sat Nov 15 | vsJets | L3-4 (SO) | 5-12-3 | 13 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 21 | Tue Nov 18 | atBlackhawks | L2-5 | 5-13-3 | 13 PTS | United Center · Chicago, IL |
| 22 | Wed Nov 19 | at Sabres | W6-2 | 6-13-3 | 15 PTS | KeyBank Center · Buffalo, NY |
| 23 | Sat Nov 22 | vs Stars | W3-2 (SO) | 7-13-3 | 17 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 24 | Sun Nov 23 | atCanucks | W5-2 | 8-13-3 | 19 PTS | Rogers Arena · Vancouver, British Columbia |
| 25 | Wed Nov 26 | at Lightning | L1-5 | 8-14-3 | 19 PTS | Benchmark International Arena · Tampa, FL |
| 26 | Fri Nov 28 | at Panthers | W5-3 | 9-14-3 | 21 PTS | Amerant Bank Arena · Sunrise, FL |
| 27 | Sun Nov 30 | at Hurricanes | L0-1 (OT) | 9-14-4 | 22 PTS | PNC Arena · Raleigh, NC |
| 28 | Tue Dec 2 | atPredators | L1-5 | 9-15-4 | 22 PTS | Bridgestone Arena · Nashville, TN |
| 29 | Thu Dec 4 | vsWild | W4-1 | 10-15-4 | 24 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 30 | Sat Dec 6 | vsMammoth | W2-0 | 11-15-4 | 26 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 31 | Mon Dec 8 | vsSabres | W7-4 | 12-15-4 | 28 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 32 | Wed Dec 10 | vs Red Wings | L3-4 | 12-16-4 | 28 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 33 | Sat Dec 13 | at Kings | W2-1 (OT) | 13-16-4 | 30 PTS | Crypto.com Arena · Los Angeles, CA |
| 34 | Tue Dec 16 | atSharks | L3-6 | 13-17-4 | 30 PTS | SAP Center · San Jose, CA |
| 35 | Thu Dec 18 | vs Kraken | W4-2 | 14-17-4 | 32 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 36 | Sat Dec 20 | vsKnights | W6-3 | 15-17-4 | 34 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 37 | Tue Dec 23 | atOilers | L1-5 | 15-18-4 | 34 PTS | Rogers Place · Edmonton, AB |
| 38 | Sat Dec 27 | vsOilers | W3-2 | 16-18-4 | 36 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 39 | Mon Dec 29 | vs Bruins | W2-1 (OT) | 17-18-4 | 38 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 40 | Wed Dec 31 | vsFlyers | W5-1 | 18-18-4 | 40 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 41 | Sat Jan 3 | vsPredators | L3-4 | 18-19-4 | 40 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 42 | Mon Jan 5 | vsKraken | L1-5 | 18-20-4 | 40 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 43 | Wed Jan 7 | atCanadiens | L1-4 | 18-21-4 | 40 PTS | Bell Centre · Montreal, QC |
| 44 | Thu Jan 8 | atBruins | L1-4 | 18-22-4 | 40 PTS | TD Garden · Boston, MA |
| 45 | Sat Jan 10 | at Penguins | W2-1 | 19-22-4 | 42 PTS | PPG Paints Arena · Pittsburgh, PA |
| 46 | Tue Jan 13 | atJackets | L3-5 | 19-23-4 | 42 PTS | Nationwide Arena · Columbus, OH |
| 47 | Thu Jan 15 | atBlackhawks | W3-1 | 20-23-4 | 44 PTS | United Center · Chicago, IL |
| 48 | Sat Jan 17 | vs Islanders | W4-2 | 21-23-4 | 46 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 49 | Mon Jan 19 | vs Devils | L1-2 (OT) | 21-23-5 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 50 | Wed Jan 21 | vsPenguins | L1-4 | 21-24-5 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 51 | Fri Jan 23 | vs Capitals | L1-3 | 21-25-5 | 47 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 52 | Sun Jan 25 | vs Ducks | L3-4 (OT) | 21-25-6 | 48 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 53 | Thu Jan 29 | atWild | L1-4 | 21-26-6 | 48 PTS | Xcel Energy Center · St. Paul, MN |
| 54 | Sat Jan 31 | vsSharks | W3-2 | 22-26-6 | 50 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 55 | Mon Feb 2 | vsMaple Leafs | L2-4 | 22-27-6 | 50 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 56 | Wed Feb 4 | vsOilers | W4-3 | 23-27-6 | 52 PTS | Scotiabank Saddledome · Calgary, Alberta |
Avalanche