| 1 | Wed Oct 8 | vs Flames | L3-4 (SO) | 0-0-1 | 1 PTS | Rogers Place · Edmonton, AB |
| 2 | Sat Oct 11 | vs Canucks | W3-1 | 1-0-1 | 3 PTS | Rogers Place · Edmonton, AB |
| 3 | Tue Oct 14 | at Rangers | W2-0 | 2-0-1 | 5 PTS | Madison Square Garden · Manhattan, NY |
| 4 | Thu Oct 16 | at Islanders | L2-4 | 2-1-1 | 5 PTS | UBS Arena · Elmont, NY |
| 5 | Sat Oct 18 | at Devils | L3-5 | 2-2-1 | 5 PTS | Prudential Center · Newark, NJ |
| 6 | Sun Oct 19 | at Red Wings | L2-4 | 2-3-1 | 5 PTS | Little Caesars Arena · Detroit, MI |
| 7 | Tue Oct 21 | at Senators | W3-2 (OT) | 3-3-1 | 7 PTS | Canadian Tire Centre · Ottawa, ON |
| 8 | Thu Oct 23 | vs Canadiens | W6-5 | 4-3-1 | 9 PTS | Rogers Place · Edmonton, AB |
| 9 | Sat Oct 25 | at Kraken | L2-3 | 4-4-1 | 9 PTS | Climate Pledge Arena · Seattle, WA |
| 10 | Sun Oct 26 | atCanucks | L3-4 (OT) | 4-4-2 | 10 PTS | Rogers Arena · Vancouver, British Columbia |
| 11 | Tue Oct 28 | vs Mammoth | W6-3 | 5-4-2 | 12 PTS | Rogers Place · Edmonton, AB |
| 12 | Thu Oct 30 | vsRangers | L3-4 (OT) | 5-4-3 | 13 PTS | Rogers Place · Edmonton, AB |
| 13 | Sat Nov 1 | vs Blackhawks | W3-2 (OT) | 6-4-3 | 15 PTS | Rogers Place · Edmonton, AB |
| 14 | Mon Nov 3 | at Blues | L2-3 | 6-5-3 | 15 PTS | Enterprise Center · St. Louis, MO |
| 15 | Tue Nov 4 | at Stars | L3-4 (SO) | 6-5-4 | 16 PTS | American Airlines Center · Dallas, TX |
| 16 | Sat Nov 8 | vs Avalanche | L1-9 | 6-6-4 | 16 PTS | Rogers Place · Edmonton, AB |
| 17 | Mon Nov 10 | vs Jackets | W5-4 (OT) | 7-6-4 | 18 PTS | Rogers Place · Edmonton, AB |
| 18 | Wed Nov 12 | at Flyers | W2-1 (OT) | 8-6-4 | 20 PTS | Wells Fargo Center · Philadelphia, PA |
| 19 | Thu Nov 13 | atJackets | L4-5 | 8-7-4 | 20 PTS | Nationwide Arena · Columbus, OH |
| 20 | Sat Nov 15 | at Hurricanes | W4-3 (OT) | 9-7-4 | 22 PTS | PNC Arena · Raleigh, NC |
| 21 | Mon Nov 17 | at Sabres | L1-5 | 9-8-4 | 22 PTS | KeyBank Center · Buffalo, NY |
| 22 | Wed Nov 19 | at Capitals | L4-7 | 9-9-4 | 22 PTS | Capital One Arena · Washington, D.C. |
| 23 | Thu Nov 20 | at Lightning | L1-2 (OT) | 9-9-5 | 23 PTS | Benchmark International Arena · Tampa, FL |
| 24 | Sat Nov 22 | at Panthers | W6-3 | 10-9-5 | 25 PTS | Amerant Bank Arena · Sunrise, FL |
| 25 | Tue Nov 25 | vsStars | L3-8 | 10-10-5 | 25 PTS | Rogers Place · Edmonton, AB |
| 26 | Sat Nov 29 | atKraken | W4-0 | 11-10-5 | 27 PTS | Climate Pledge Arena · Seattle, WA |
| 27 | Tue Dec 2 | vs Wild | L0-1 | 11-11-5 | 27 PTS | Rogers Place · Edmonton, AB |
| 28 | Thu Dec 4 | vsKraken | W9-4 | 12-11-5 | 29 PTS | Rogers Place · Edmonton, AB |
| 29 | Sat Dec 6 | vs Jets | W6-2 | 13-11-5 | 31 PTS | Rogers Place · Edmonton, AB |
| 30 | Tue Dec 9 | vsSabres | L3-4 (OT) | 13-11-6 | 32 PTS | Rogers Place · Edmonton, AB |
| 31 | Thu Dec 11 | vsRed Wings | W4-1 | 14-11-6 | 34 PTS | Rogers Place · Edmonton, AB |
| 32 | Sat Dec 13 | at Maple Leafs | W6-3 | 15-11-6 | 36 PTS | Scotiabank Arena · Toronto, ON |
| 33 | Sun Dec 14 | atCanadiens | L1-4 | 15-12-6 | 36 PTS | Bell Centre · Montreal, QC |
| 34 | Tue Dec 16 | at Penguins | W6-4 | 16-12-6 | 38 PTS | PPG Paints Arena · Pittsburgh, PA |
| 35 | Thu Dec 18 | at Bruins | W3-1 | 17-12-6 | 40 PTS | TD Garden · Boston, MA |
| 36 | Sat Dec 20 | atWild | L2-5 | 17-13-6 | 40 PTS | Xcel Energy Center · St. Paul, MN |
| 37 | Sun Dec 21 | vs Knights | W4-3 | 18-13-6 | 42 PTS | Rogers Place · Edmonton, AB |
| 38 | Tue Dec 23 | vsFlames | W5-1 | 19-13-6 | 44 PTS | Rogers Place · Edmonton, AB |
| 39 | Sat Dec 27 | atFlames | L2-3 | 19-14-6 | 44 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 40 | Mon Dec 29 | atJets | W3-1 | 20-14-6 | 46 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 41 | Wed Dec 31 | vsBruins | L2-6 | 20-15-6 | 46 PTS | Rogers Place · Edmonton, AB |
| 42 | Sat Jan 3 | vsFlyers | L2-5 | 20-16-6 | 46 PTS | Rogers Place · Edmonton, AB |
| 43 | Tue Jan 6 | vs Predators | W6-2 | 21-16-6 | 48 PTS | Rogers Place · Edmonton, AB |
| 44 | Thu Jan 8 | atJets | W4-3 | 22-16-6 | 50 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 45 | Sat Jan 10 | vs Kings | L3-4 (SO) | 22-16-7 | 51 PTS | Rogers Place · Edmonton, AB |
| 46 | Mon Jan 12 | atBlackhawks | W4-1 | 23-16-7 | 53 PTS | United Center · Chicago, IL |
| 47 | Tue Jan 13 | atPredators | L3-4 (OT) | 23-16-8 | 54 PTS | Bridgestone Arena · Nashville, TN |
| 48 | Thu Jan 15 | vsIslanders | L0-1 | 23-17-8 | 54 PTS | Rogers Place · Edmonton, AB |
| 49 | Sat Jan 17 | atCanucks | W6-0 | 24-17-8 | 56 PTS | Rogers Arena · Vancouver, British Columbia |
| 50 | Sun Jan 18 | vsBlues | W5-0 | 25-17-8 | 58 PTS | Rogers Place · Edmonton, AB |
| 51 | Tue Jan 20 | vsDevils | L1-2 | 25-18-8 | 58 PTS | Rogers Place · Edmonton, AB |
| 52 | Thu Jan 22 | vsPenguins | L2-6 | 25-19-8 | 58 PTS | Rogers Place · Edmonton, AB |
| 53 | Sat Jan 24 | vsCapitals | W6-5 (OT) | 26-19-8 | 60 PTS | Rogers Place · Edmonton, AB |
| 54 | Mon Jan 26 | vs Ducks | W7-4 | 27-19-8 | 62 PTS | Rogers Place · Edmonton, AB |
| 55 | Thu Jan 29 | vs Sharks | W4-3 (OT) | 28-19-8 | 64 PTS | Rogers Place · Edmonton, AB |
| 56 | Sat Jan 31 | vsWild | L3-7 | 28-20-8 | 64 PTS | Rogers Place · Edmonton, AB |
| 57 | Tue Feb 3 | vsMaple Leafs | L2-5 | 28-21-8 | 64 PTS | Rogers Place · Edmonton, AB |
| 58 | Wed Feb 4 | atFlames | L3-4 | 28-22-8 | 64 PTS | Scotiabank Saddledome · Calgary, Alberta |
