| 1 | Tue Oct 7 | at Rangers | W3-0 | 1-0-0 | 2 PTS | Madison Square Garden · Manhattan, NY |
| 2 | Thu Oct 9 | vs Islanders | W4-3 | 2-0-0 | 4 PTS | PPG Paints Arena · Pittsburgh, PA |
| 3 | Sat Oct 11 | vsRangers | L1-6 | 2-1-0 | 4 PTS | PPG Paints Arena · Pittsburgh, PA |
| 4 | Tue Oct 14 | at Ducks | L3-4 | 2-2-0 | 4 PTS | Honda Center · Anaheim, CA |
| 5 | Thu Oct 16 | at Kings | W4-2 | 3-2-0 | 6 PTS | Crypto.com Arena · Los Angeles, CA |
| 6 | Sat Oct 18 | at Sharks | W3-0 | 4-2-0 | 8 PTS | SAP Center · San Jose, CA |
| 7 | Tue Oct 21 | vs Canucks | W5-1 | 5-2-0 | 10 PTS | PPG Paints Arena · Pittsburgh, PA |
| 8 | Thu Oct 23 | at Panthers | W5-3 | 6-2-0 | 12 PTS | Amerant Bank Arena · Sunrise, FL |
| 9 | Sat Oct 25 | vs Jackets | L4-5 (SO) | 6-2-1 | 13 PTS | PPG Paints Arena · Pittsburgh, PA |
| 10 | Mon Oct 27 | vs Blues | W6-3 | 7-2-1 | 15 PTS | PPG Paints Arena · Pittsburgh, PA |
| 11 | Tue Oct 28 | at Flyers | L2-3 (SO) | 7-2-2 | 16 PTS | Wells Fargo Center · Philadelphia, PA |
| 12 | Thu Oct 30 | at Wild | W4-1 | 8-2-2 | 18 PTS | Xcel Energy Center · St. Paul, MN |
| 13 | Sat Nov 1 | at Jets | L2-5 | 8-3-2 | 18 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 14 | Mon Nov 3 | at Maple Leafs | L3-4 | 8-4-2 | 18 PTS | Scotiabank Arena · Toronto, ON |
| 15 | Thu Nov 6 | vs Capitals | W5-3 | 9-4-2 | 20 PTS | PPG Paints Arena · Pittsburgh, PA |
| 16 | Sat Nov 8 | at Devils | L1-2 (SO) | 9-4-3 | 21 PTS | Prudential Center · Newark, NJ |
| 17 | Sun Nov 9 | vsKings | L2-3 | 9-5-3 | 21 PTS | PPG Paints Arena · Pittsburgh, PA |
| 18 | Fri Nov 14 | at Predators | L1-2 (OT) | 9-5-4 | 22 PTS | Bridgestone Arena · Nashville, TN |
| 19 | Sun Nov 16 | vsPredators | W4-0 | 10-5-4 | 24 PTS | PPG Paints Arena · Pittsburgh, PA |
| 20 | Fri Nov 21 | vsWild | L0-5 | 10-6-4 | 24 PTS | PPG Paints Arena · Pittsburgh, PA |
| 21 | Sat Nov 22 | vs Kraken | L2-3 (OT) | 10-6-5 | 25 PTS | PPG Paints Arena · Pittsburgh, PA |
| 22 | Wed Nov 26 | vs Sabres | W4-2 | 11-6-5 | 27 PTS | PPG Paints Arena · Pittsburgh, PA |
| 23 | Fri Nov 28 | atJackets | W4-3 (OT) | 12-6-5 | 29 PTS | Nationwide Arena · Columbus, OH |
| 24 | Sat Nov 29 | vsMaple Leafs | L2-7 | 12-7-5 | 29 PTS | PPG Paints Arena · Pittsburgh, PA |
| 25 | Mon Dec 1 | atFlyers | W5-1 | 13-7-5 | 31 PTS | Wells Fargo Center · Philadelphia, PA |
| 26 | Thu Dec 4 | at Lightning | W4-3 | 14-7-5 | 33 PTS | Benchmark International Arena · Tampa, FL |
| 27 | Sun Dec 7 | at Stars | L2-3 (SO) | 14-7-6 | 34 PTS | American Airlines Center · Dallas, TX |
| 28 | Tue Dec 9 | vsDucks | L3-4 (SO) | 14-7-7 | 35 PTS | PPG Paints Arena · Pittsburgh, PA |
| 29 | Thu Dec 11 | vs Canadiens | L2-4 | 14-8-7 | 35 PTS | PPG Paints Arena · Pittsburgh, PA |
| 30 | Sat Dec 13 | vsSharks | L5-6 (OT) | 14-8-8 | 36 PTS | PPG Paints Arena · Pittsburgh, PA |
| 31 | Sun Dec 14 | vs Mammoth | L4-5 (OT) | 14-8-9 | 37 PTS | PPG Paints Arena · Pittsburgh, PA |
| 32 | Tue Dec 16 | vs Oilers | L4-6 | 14-9-9 | 37 PTS | PPG Paints Arena · Pittsburgh, PA |
| 33 | Thu Dec 18 | at Senators | L0-4 | 14-10-9 | 37 PTS | Canadian Tire Centre · Ottawa, ON |
| 34 | Sat Dec 20 | atCanadiens | L0-4 | 14-11-9 | 37 PTS | Bell Centre · Montreal, QC |
| 35 | Sun Dec 21 | vsCanadiens | W4-3 (SO) | 15-11-9 | 39 PTS | PPG Paints Arena · Pittsburgh, PA |
| 36 | Tue Dec 23 | atMaple Leafs | L3-6 | 15-12-9 | 39 PTS | Scotiabank Arena · Toronto, ON |
| 37 | Sun Dec 28 | at Blackhawks | W7-3 | 16-12-9 | 41 PTS | United Center · Chicago, IL |
| 38 | Tue Dec 30 | vs Hurricanes | W5-1 | 17-12-9 | 43 PTS | PPG Paints Arena · Pittsburgh, PA |
| 39 | Thu Jan 1 | vs Red Wings | W4-3 (OT) | 18-12-9 | 45 PTS | PPG Paints Arena · Pittsburgh, PA |
| 40 | Sat Jan 3 | atRed Wings | W4-1 | 19-12-9 | 47 PTS | Little Caesars Arena · Detroit, MI |
| 41 | Sun Jan 4 | atJackets | W5-4 (OT) | 20-12-9 | 49 PTS | Nationwide Arena · Columbus, OH |
| 42 | Thu Jan 8 | vsDevils | W4-1 | 21-12-9 | 51 PTS | PPG Paints Arena · Pittsburgh, PA |
| 43 | Sat Jan 10 | vs Flames | L1-2 | 21-13-9 | 51 PTS | PPG Paints Arena · Pittsburgh, PA |
| 44 | Sun Jan 11 | at Bruins | L0-1 | 21-14-9 | 51 PTS | TD Garden · Boston, MA |
| 45 | Tue Jan 13 | vsLightning | L1-2 (SO) | 21-14-10 | 52 PTS | PPG Paints Arena · Pittsburgh, PA |
| 46 | Thu Jan 15 | vsFlyers | W6-3 | 22-14-10 | 54 PTS | PPG Paints Arena · Pittsburgh, PA |
| 47 | Sat Jan 17 | vsJackets | L3-4 (SO) | 22-14-11 | 55 PTS | PPG Paints Arena · Pittsburgh, PA |
| 48 | Mon Jan 19 | atKraken | W6-3 | 23-14-11 | 57 PTS | Climate Pledge Arena · Seattle, WA |
| 49 | Wed Jan 21 | atFlames | W4-1 | 24-14-11 | 59 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 50 | Thu Jan 22 | atOilers | W6-2 | 25-14-11 | 61 PTS | Rogers Place · Edmonton, AB |
| 51 | Sun Jan 25 | atCanucks | W3-2 | 26-14-11 | 63 PTS | Rogers Arena · Vancouver, British Columbia |
| 52 | Thu Jan 29 | vsBlackhawks | W6-2 | 27-14-11 | 65 PTS | PPG Paints Arena · Pittsburgh, PA |
| 53 | Sat Jan 31 | vsRangers | W6-5 | 28-14-11 | 67 PTS | PPG Paints Arena · Pittsburgh, PA |
| 54 | Mon Feb 2 | vsSenators | L2-3 | 28-15-11 | 67 PTS | PPG Paints Arena · Pittsburgh, PA |
| 55 | Tue Feb 3 | atIslanders | L4-5 (OT) | 28-15-12 | 68 PTS | UBS Arena · Elmont, NY |
| 56 | Thu Feb 5 | atSabres | W5-2 | 29-15-12 | 70 PTS | KeyBank Center · Buffalo, NY |
Knights
Avalanche