| 1 | Thu Oct 9 | at Predators | L1-2 | 0-1-0 | 0 PTS | Bridgestone Arena · Nashville, TN |
| 2 | Sat Oct 11 | at Wild | W7-4 | 1-1-0 | 2 PTS | Xcel Energy Center · St. Paul, MN |
| 3 | Mon Oct 13 | vs Devils | L2-3 | 1-2-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 4 | Thu Oct 16 | vs Avalanche | L1-4 | 1-3-0 | 2 PTS | Nationwide Arena · Columbus, OH |
| 5 | Sat Oct 18 | vs Lightning | W3-2 | 2-3-0 | 4 PTS | Nationwide Arena · Columbus, OH |
| 6 | Tue Oct 21 | at Stars | W5-1 | 3-3-0 | 6 PTS | American Airlines Center · Dallas, TX |
| 7 | Fri Oct 24 | vs Capitals | L1-5 | 3-4-0 | 6 PTS | Nationwide Arena · Columbus, OH |
| 8 | Sat Oct 25 | at Penguins | W5-4 (SO) | 4-4-0 | 8 PTS | PPG Paints Arena · Pittsburgh, PA |
| 9 | Tue Oct 28 | at Sabres | W4-3 (OT) | 5-4-0 | 10 PTS | KeyBank Center · Buffalo, NY |
| 10 | Wed Oct 29 | vs Maple Leafs | W6-3 | 6-4-0 | 12 PTS | Nationwide Arena · Columbus, OH |
| 11 | Sat Nov 1 | vs Blues | W3-2 | 7-4-0 | 14 PTS | Nationwide Arena · Columbus, OH |
| 12 | Sun Nov 2 | at Islanders | L2-3 | 7-5-0 | 14 PTS | UBS Arena · Elmont, NY |
| 13 | Wed Nov 5 | at Flames | L1-5 | 7-6-0 | 14 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 14 | Sat Nov 8 | at Canucks | L3-4 | 7-7-0 | 14 PTS | Rogers Arena · Vancouver, British Columbia |
| 15 | Mon Nov 10 | at Oilers | L4-5 (OT) | 7-7-1 | 15 PTS | Rogers Place · Edmonton, AB |
| 16 | Tue Nov 11 | at Kraken | W2-1 (SO) | 8-7-1 | 17 PTS | Climate Pledge Arena · Seattle, WA |
| 17 | Thu Nov 13 | vs Oilers | W5-4 | 9-7-1 | 19 PTS | Nationwide Arena · Columbus, OH |
| 18 | Sat Nov 15 | vs Rangers | L1-2 (SO) | 9-7-2 | 20 PTS | Nationwide Arena · Columbus, OH |
| 19 | Mon Nov 17 | vs Canadiens | W4-3 (SO) | 10-7-2 | 22 PTS | Nationwide Arena · Columbus, OH |
| 20 | Tue Nov 18 | at Jets | L2-5 | 10-8-2 | 22 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 21 | Thu Nov 20 | at Maple Leafs | W3-2 (OT) | 11-8-2 | 24 PTS | Scotiabank Arena · Toronto, ON |
| 22 | Sat Nov 22 | at Red Wings | L3-4 (OT) | 11-8-3 | 25 PTS | Little Caesars Arena · Detroit, MI |
| 23 | Mon Nov 24 | at Capitals | L1-5 | 11-9-3 | 25 PTS | Capital One Arena · Washington, D.C. |
| 24 | Wed Nov 26 | vs Maple Leafs | L1-2 (OT) | 11-9-4 | 26 PTS | Nationwide Arena · Columbus, OH |
| 25 | Fri Nov 28 | vs Penguins | L3-4 (OT) | 11-9-5 | 27 PTS | Nationwide Arena · Columbus, OH |
| 26 | Mon Dec 1 | at Devils | W5-3 | 12-9-5 | 29 PTS | Prudential Center · Newark, NJ |
| 27 | Thu Dec 4 | vs Red Wings | W6-5 (SO) | 13-9-5 | 31 PTS | Nationwide Arena · Columbus, OH |
| 28 | Sat Dec 6 | at Panthers | L6-7 (OT) | 13-9-6 | 32 PTS | Amerant Bank Arena · Sunrise, FL |
| 29 | Sun Dec 7 | at Capitals | L0-2 | 13-10-6 | 32 PTS | Capital One Arena · Washington, D.C. |
| 30 | Tue Dec 9 | at Hurricanes | L1-4 | 13-11-6 | 32 PTS | PNC Arena · Raleigh, NC |
| 31 | Thu Dec 11 | vs Senators | L3-6 | 13-12-6 | 32 PTS | Nationwide Arena · Columbus, OH |
| 32 | Sat Dec 13 | vs Knights | L2-3 | 13-13-6 | 32 PTS | Nationwide Arena · Columbus, OH |
| 33 | Tue Dec 16 | vs Ducks | W4-3 (OT) | 14-13-6 | 34 PTS | Nationwide Arena · Columbus, OH |
| 34 | Thu Dec 18 | vs Wild | L2-5 | 14-14-6 | 34 PTS | Nationwide Arena · Columbus, OH |
| 35 | Sat Dec 20 | at Ducks | L3-4 | 14-15-6 | 34 PTS | Honda Center · Anaheim, CA |
| 36 | Mon Dec 22 | at Kings | W3-1 | 15-15-6 | 36 PTS | Crypto.com Arena · Los Angeles, CA |
| 37 | Sun Dec 28 | vs Islanders | W4-2 | 16-15-6 | 38 PTS | Nationwide Arena · Columbus, OH |
| 38 | Mon Dec 29 | at Senators | W4-1 | 17-15-6 | 40 PTS | Canadian Tire Centre · Ottawa, ON |
| 39 | Wed Dec 31 | vs Devils | L2-3 | 17-16-6 | 40 PTS | Nationwide Arena · Columbus, OH |
| 40 | Sat Jan 3 | vs Sabres | W5-1 | 18-16-6 | 42 PTS | Nationwide Arena · Columbus, OH |
| 41 | Sun Jan 4 | vs Penguins | L4-5 (OT) | 18-16-7 | 43 PTS | Nationwide Arena · Columbus, OH |
| 42 | Tue Jan 6 | at Sharks | L2-5 | 18-17-7 | 43 PTS | SAP Center · San Jose, CA |
| 43 | Thu Jan 8 | at Knights | L3-5 | 18-18-7 | 43 PTS | T-Mobile Arena · Las Vegas, NV |
| 44 | Sat Jan 10 | at Avalanche | L0-4 | 18-19-7 | 43 PTS | Ball Arena · Denver, CO |
| 45 | Sun Jan 11 | at Mammoth | W3-2 (OT) | 19-19-7 | 45 PTS | Delta Center · Salt Lake City, UT |
| 46 | Tue Jan 13 | vs Flames | W5-3 | 20-19-7 | 47 PTS | Nationwide Arena · Columbus, OH |
| 47 | Thu Jan 15 | vs Canucks | W4-1 | 21-19-7 | 49 PTS | Nationwide Arena · Columbus, OH |
| 48 | Sat Jan 17 | at Penguins | W4-3 (SO) | 22-19-7 | 51 PTS | PPG Paints Arena · Pittsburgh, PA |
| 49 | Tue Jan 20 | vs Senators | L1-4 | 22-20-7 | 51 PTS | Nationwide Arena · Columbus, OH |
| 50 | Thu Jan 22 | vs Stars | W1-0 | 23-20-7 | 53 PTS | Nationwide Arena · Columbus, OH |
| 51 | Sat Jan 24 | vs Lightning | W8-5 | 24-20-7 | 55 PTS | Nationwide Arena · Columbus, OH |
| 52 | Wed Jan 28 | vs Flyers | W5-3 | 25-20-7 | 57 PTS | Nationwide Arena · Columbus, OH |
| 53 | Fri Jan 30 | at Blackhawks | W4-2 | 26-20-7 | 59 PTS | United Center · Chicago, IL |
| 54 | Sat Jan 31 | at Blues | W5-3 | 27-20-7 | 61 PTS | Enterprise Center · St. Louis, MO |
| 55 | Tue Feb 3 | at Devils | W3-0 | 28-20-7 | 63 PTS | Prudential Center · Newark, NJ |
| 56 | Wed Feb 4 | vs Blackhawks | W4-0 | 29-20-7 | 65 PTS | Nationwide Arena · Columbus, OH |