| 1 | Thu Oct 9 | vs Jackets | W2-1 | 1-0-0 | 2 PTS | Bridgestone Arena · Nashville, TN |
| 2 | Sat Oct 11 | vs Mammoth | L2-3 (OT) | 1-0-1 | 3 PTS | Bridgestone Arena · Nashville, TN |
| 3 | Mon Oct 13 | at Senators | W4-1 | 2-0-1 | 5 PTS | Canadian Tire Centre · Ottawa, ON |
| 4 | Tue Oct 14 | at Maple Leafs | L4-7 | 2-1-1 | 5 PTS | Scotiabank Arena · Toronto, ON |
| 5 | Thu Oct 16 | at Canadiens | L2-3 (OT) | 2-1-2 | 6 PTS | Bell Centre · Montreal, QC |
| 6 | Sat Oct 18 | at Jets | L1-4 | 2-2-2 | 6 PTS | Canada Life Centre · Winnipeg, Manitoba |
| 7 | Tue Oct 21 | vs Ducks | L2-5 | 2-3-2 | 6 PTS | Bridgestone Arena · Nashville, TN |
| 8 | Thu Oct 23 | vs Canucks | W2-1 | 3-3-2 | 8 PTS | Bridgestone Arena · Nashville, TN |
| 9 | Sat Oct 25 | vs Kings | W5-4 (SO) | 4-3-2 | 10 PTS | Bridgestone Arena · Nashville, TN |
| 10 | Sun Oct 26 | vs Stars | L2-3 | 4-4-2 | 10 PTS | Bridgestone Arena · Nashville, TN |
| 11 | Tue Oct 28 | vs Lightning | L2-5 | 4-5-2 | 10 PTS | Bridgestone Arena · Nashville, TN |
| 12 | Thu Oct 30 | at Flyers | L1-4 | 4-6-2 | 10 PTS | Wells Fargo Center · Philadelphia, PA |
| 13 | Sat Nov 1 | vs Flames | W4-2 | 5-6-2 | 12 PTS | Bridgestone Arena · Nashville, TN |
| 14 | Mon Nov 3 | vsCanucks | L4-5 (OT) | 5-6-3 | 13 PTS | Bridgestone Arena · Nashville, TN |
| 15 | Tue Nov 4 | at Wild | L2-3 (OT) | 5-6-4 | 14 PTS | Xcel Energy Center · St. Paul, MN |
| 16 | Thu Nov 6 | vsFlyers | L1-3 | 5-7-4 | 14 PTS | Bridgestone Arena · Nashville, TN |
| 17 | Sat Nov 8 | vsStars | L4-5 | 5-8-4 | 14 PTS | Bridgestone Arena · Nashville, TN |
| 18 | Mon Nov 10 | at Rangers | L3-6 | 5-9-4 | 14 PTS | Madison Square Garden · Manhattan, NY |
| 19 | Fri Nov 14 | vs Penguins | W2-1 (OT) | 6-9-4 | 16 PTS | Bridgestone Arena · Nashville, TN |
| 20 | Sun Nov 16 | atPenguins | L0-4 | 6-10-4 | 16 PTS | PPG Paints Arena · Pittsburgh, PA |
| 21 | Sat Nov 22 | vs Avalanche | L0-3 | 6-11-4 | 16 PTS | Bridgestone Arena · Nashville, TN |
| 22 | Mon Nov 24 | vs Panthers | L3-8 | 6-12-4 | 16 PTS | Bridgestone Arena · Nashville, TN |
| 23 | Wed Nov 26 | at Red Wings | W6-3 | 7-12-4 | 18 PTS | Little Caesars Arena · Detroit, MI |
| 24 | Fri Nov 28 | at Blackhawks | W4-3 | 8-12-4 | 20 PTS | United Center · Chicago, IL |
| 25 | Sat Nov 29 | vsJets | L2-5 | 8-13-4 | 20 PTS | Bridgestone Arena · Nashville, TN |
| 26 | Tue Dec 2 | vsFlames | W5-1 | 9-13-4 | 22 PTS | Bridgestone Arena · Nashville, TN |
| 27 | Thu Dec 4 | atPanthers | W2-1 (OT) | 10-13-4 | 24 PTS | Amerant Bank Arena · Sunrise, FL |
| 28 | Sat Dec 6 | at Hurricanes | L3-6 | 10-14-4 | 24 PTS | PNC Arena · Raleigh, NC |
| 29 | Tue Dec 9 | vsAvalanche | W4-3 (SO) | 11-14-4 | 26 PTS | Bridgestone Arena · Nashville, TN |
| 30 | Thu Dec 11 | vs Blues | W7-2 | 12-14-4 | 28 PTS | Bridgestone Arena · Nashville, TN |
| 31 | Sat Dec 13 | atAvalanche | L2-4 | 12-15-4 | 28 PTS | Ball Arena · Denver, CO |
| 32 | Mon Dec 15 | atBlues | W5-2 | 13-15-4 | 30 PTS | Enterprise Center · St. Louis, MO |
| 33 | Wed Dec 17 | vsHurricanes | L1-4 | 13-16-4 | 30 PTS | Bridgestone Arena · Nashville, TN |
| 34 | Sat Dec 20 | vsMaple Leafs | W5-3 | 14-16-4 | 32 PTS | Bridgestone Arena · Nashville, TN |
| 35 | Sun Dec 21 | vsRangers | W2-1 | 15-16-4 | 34 PTS | Bridgestone Arena · Nashville, TN |
| 36 | Tue Dec 23 | atWild | W3-2 (OT) | 16-16-4 | 36 PTS | Xcel Energy Center · St. Paul, MN |
| 37 | Sat Dec 27 | atBlues | L2-3 | 16-17-4 | 36 PTS | Enterprise Center · St. Louis, MO |
| 38 | Mon Dec 29 | atMammoth | W4-3 | 17-17-4 | 38 PTS | Delta Center · Salt Lake City, UT |
| 39 | Wed Dec 31 | at Knights | W4-2 | 18-17-4 | 40 PTS | T-Mobile Arena · Las Vegas, NV |
| 40 | Thu Jan 1 | at Kraken | L1-4 | 18-18-4 | 40 PTS | Climate Pledge Arena · Seattle, WA |
| 41 | Sat Jan 3 | atFlames | W4-3 | 19-18-4 | 42 PTS | Scotiabank Saddledome · Calgary, Alberta |
| 42 | Tue Jan 6 | at Oilers | L2-6 | 19-19-4 | 42 PTS | Rogers Place · Edmonton, AB |
| 43 | Thu Jan 8 | vs Islanders | W2-1 (SO) | 20-19-4 | 44 PTS | Bridgestone Arena · Nashville, TN |
| 44 | Sat Jan 10 | vsBlackhawks | L0-3 | 20-20-4 | 44 PTS | Bridgestone Arena · Nashville, TN |
| 45 | Sun Jan 11 | vs Capitals | W3-2 | 21-20-4 | 46 PTS | Bridgestone Arena · Nashville, TN |
| 46 | Tue Jan 13 | vsOilers | W4-3 (OT) | 22-20-4 | 48 PTS | Bridgestone Arena · Nashville, TN |
| 47 | Fri Jan 16 | atAvalanche | W7-3 | 23-20-4 | 50 PTS | Ball Arena · Denver, CO |
| 48 | Sat Jan 17 | atKnights | L2-7 | 23-21-4 | 50 PTS | T-Mobile Arena · Las Vegas, NV |
| 49 | Tue Jan 20 | vs Sabres | L3-5 | 23-22-4 | 50 PTS | Bridgestone Arena · Nashville, TN |
| 50 | Thu Jan 22 | vsSenators | W5-3 | 24-22-4 | 52 PTS | Bridgestone Arena · Nashville, TN |
| 51 | Sat Jan 24 | vsMammoth | L2-5 | 24-23-4 | 52 PTS | Bridgestone Arena · Nashville, TN |
| 52 | Tue Jan 27 | at Bruins | L2-3 (OT) | 24-23-5 | 53 PTS | TD Garden · Boston, MA |
| 53 | Thu Jan 29 | at Devils | L2-3 (OT) | 24-23-6 | 54 PTS | Prudential Center · Newark, NJ |
| 54 | Sat Jan 31 | atIslanders | W4-3 | 25-23-6 | 56 PTS | UBS Arena · Elmont, NY |
| 55 | Mon Feb 2 | vsBlues | W6-5 | 26-23-6 | 58 PTS | Bridgestone Arena · Nashville, TN |
| 56 | Wed Feb 4 | vsWild | L5-6 (OT) | 26-23-7 | 59 PTS | Bridgestone Arena · Nashville, TN |
| 57 | Thu Feb 5 | atCapitals | L2-4 | 26-24-7 | 59 PTS | Capital One Arena · Washington, D.C. |
Sharks