| 1 | Mon Nov 3 | vs N'Western St | W98-68 | 1-0 | 1.000 | - | SECN+ | Reed Arena · College Station, TX |
| 2 | Thu Nov 6 | vs Texas So | W104-70 | 2-0 | 1.000 | - | SECN+ | Reed Arena · College Station, TX |
| 3 | Sun Nov 9 | at Oklahoma St | L63-87 | 2-1 | .667 | - | ESPN2 | Gallagher-Iba Arena · Stillwater, OK |
| 4 | Fri Nov 14 | vs UCF | L74-86 | 2-2 | .500 | - | SECN+ | Reed Arena · College Station, TX |
| 5 | Tue Nov 18 | vs Montana | W86-81 | 3-2 | .600 | - | SECN+ | Reed Arena · College Station, TX |
| 6 | Fri Nov 21 | vs Manhattan | W109-68 | 4-2 | .667 | - | SECN+ | Reed Arena · College Station, TX |
| 7 | Tue Nov 25 | vs Miss Valley St | W120-84 | 5-2 | .714 | - | SECN+ | Reed Arena · College Station, TX |
| 8 | Fri Nov 28 | at Florida St | W95-59 | 6-2 | .750 | - | ESPN2 | Donald L. Tucker Center · Tallahassee, FL |
| 9 | Tue Dec 2 | at Pitt | W81-73 | 7-2 | .778 | - | ESPNU | Petersen Events Center · Pittsburgh, PA |
| 10 | Sun Dec 7 | at SMU | L80-93 (OT) | 7-3 | .700 | - | ESPN2 | College Park Center · Arlington, TX |
| 11 | Sun Dec 14 | vs Jacksonville | W112-75 | 8-3 | .727 | - | SEC Network | Reed Arena · College Station, TX |
| 12 | Sun Dec 21 | vs E Texas A&M | W118-77 | 9-3 | .750 | - | SECN+ | Reed Arena · College Station, TX |
| 13 | Mon Dec 29 | vs Prairie View | W111-82 | 10-3 | .769 | - | SECN+ | Reed Arena · College Station, TX |
| 14 | Sat Jan 3 | vs LSU | W75-72 | 11-3 | .786 | - | ESPNU | Reed Arena · College Station, TX |
| 15 | Tue Jan 6 | at Auburn | W90-88 | 12-3 | .800 | - | SEC Network | Neville Arena · Auburn, AL |
| 16 | Sat Jan 10 | vs Oklahoma | W83-76 | 13-3 | .813 | - | SEC Network | Reed Arena · College Station, TX |
| 17 | Tue Jan 13 | at #24Tennessee | L82-87 (2OT) | 13-4 | .765 | - | SEC Network | Thompson-Boling Arena · Knoxville, TN |
| 18 | Sat Jan 17 | at Texas | W74-70 | 14-4 | .778 | - | ESPN | Moody Center · Austin, TX |
| 19 | Wed Jan 21 | vs Mississippi St | W88-68 | 15-4 | .789 | - | SEC Network | Reed Arena · College Station, TX |
| 20 | Sat Jan 24 | vs South Carolina | W92-69 | 16-4 | .800 | - | SECN+ | Reed Arena · College Station, TX |
| 21 | Sat Jan 31 | at Georgia | W92-77 | 17-4 | .810 | - | SEC Network | Stegeman Coliseum · Athens, GA |
| 22 | Wed Feb 4 | at Alabama | L97-100 | 17-5 | .773 | - | SEC Network | Coleman Coliseum · Tuscaloosa, AL |
| 23 | Sat Feb 7 | vs #17Florida | L67-86 | 17-6 | .739 | - | SEC Network | Reed Arena · College Station, TX |
Missouri
#19Vanderbilt
Ole Miss
#21Arkansas
#25Kentucky