| 1 | Mon Nov 3 | vs TBD | W95-48 | 1-0 | 1.000 | - | | William Nicks Building · Prairie View, TX |
| 2 | Wed Nov 5 | vsTBD | W94-53 | 2-0 | 1.000 | - | | William Nicks Building · Prairie View, TX |
| 3 | Sat Nov 8 | at Wichita St | L62-105 | 2-1 | .667 | - | ESPN+ | Charles Koch Arena · Wichita, KS |
| 4 | Wed Nov 12 | at Oklahoma St | L67-94 | 2-2 | .500 | - | ESPN+ | Gallagher-Iba Arena · Stillwater, OK |
| 5 | Mon Nov 17 | at Missouri | L73-91 | 2-3 | .400 | - | SECN+ | Mizzou Arena · Columbia, MO |
| 6 | Sat Nov 22 | vs UT Martin | L68-69 | 2-4 | .333 | - | | William Nicks Building · Prairie View, TX |
| 7 | Sun Nov 23 | at North Florida | W85-82 | 3-4 | .429 | - | | UNF Arena · Jacksonville, FL |
| 8 | Sun Nov 30 | at North Texas | L69-72 | 3-5 | .375 | - | ESPN+ | The Super Pit · Denton, TX |
| 9 | Sat Dec 6 | vsTBD | W124-62 | 4-5 | .444 | - | | William Nicks Building · Prairie View, TX |
| 10 | Sat Dec 13 | at South Dakota | L85-97 | 4-6 | .400 | - | | Sanford Coyote Sports Center · Vermillion, SD |
| 11 | Sat Dec 20 | vsTBD | W100-64 | 5-6 | .455 | - | | William Nicks Building · Prairie View, TX |
| 12 | Mon Dec 22 | at LSU | L90-104 | 5-7 | .417 | - | SEC Network | Pete Maravich Assembly Center · Baton Rouge, LA |
| 13 | Mon Dec 29 | at Texas A&M | L82-111 | 5-8 | .385 | - | SECN+ | Reed Arena · College Station, TX |
| 14 | Sat Jan 3 | at Grambling | L72-76 | 5-9 | .357 | - | | Fredrick C. Hobdy Assembly Center · Grambling, LA |
| 15 | Mon Jan 5 | at Southern | W89-85 | 6-9 | .400 | - | | F. G. Clark Activity Center · Baton Rouge, LA |
| 16 | Sat Jan 10 | vs Miss Valley St | W70-69 | 7-9 | .438 | - | | William Nicks Building · Prairie View, TX |
| 17 | Mon Jan 12 | vs AR-Pine Bluff | W73-61 | 8-9 | .471 | - | | William Nicks Building · Prairie View, TX |
| 18 | Sat Jan 17 | at Jackson St | L78-82 | 8-10 | .444 | - | | Lee E. Williams Athletic and Assembly Center · Jackson, MS |
| 19 | Mon Jan 19 | at Alcorn St | L75-76 | 8-11 | .421 | - | | Davey L. Whitney Complex · Lorman, MS |
| 20 | Sat Jan 24 | vs Alabama St | L80-95 | 8-12 | .400 | - | | William Nicks Building · Prairie View, TX |
| 21 | Mon Jan 26 | vs Alabama A&M | PPD | 9-15 | .375 | - | | William Nicks Building · Prairie View, TX |
| 22 | Tue Jan 27 | vsAlabama A&M | L60-80 | 8-13 | .381 | - | | William Nicks Building · Prairie View, TX |
| 23 | Sat Jan 31 | vs Texas So | W85-78 | 9-13 | .409 | - | | William Nicks Building · Prairie View, TX |
| 24 | Sat Feb 7 | at Bethune | L76-82 | 9-14 | .391 | - | | Moore Gymnasium (FL) · Daytona Beach, FL |
| 25 | Mon Feb 9 | at FAMU | L96-100 | 9-15 | .375 | - | | Al Lawson Center · Tallahassee, FL |
