| 1 | Sun Sep 7 | vs 49ers | L13-17 | 0-1 | .000 | Lumen Field · Seattle, WA |
| 2 | Sun Sep 14 | at Steelers | W31-17 | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sun Sep 21 | vs Saints | W44-13 | 2-1 | .667 | Lumen Field · Seattle, WA |
| 4 | Thu Sep 25 | at Cardinals | W23-20 | 3-1 | .750 | State Farm Stadium · Glendale, AZ |
| 5 | Sun Oct 5 | vs Buccaneers | L35-38 | 3-2 | .600 | Lumen Field · Seattle, WA |
| 6 | Sun Oct 12 | at Jaguars | W20-12 | 4-2 | .667 | TIAA Bank Field · Jacksonville, FL |
| 7 | Mon Oct 20 | vs Texans | W27-19 | 5-2 | .714 | Lumen Field · Seattle, WA |
| --bye week-- |
| 9 | Sun Nov 2 | at Commanders | W38-14 | 6-2 | .750 | FedEx Field · North Englewood, MD |
| 10 | Sun Nov 9 | vsCardinals | W44-22 | 7-2 | .778 | Lumen Field · Seattle, WA |
| 11 | Sun Nov 16 | at Rams | L19-21 | 7-3 | .700 | SoFi Stadium · Inglewood, CA |
| 12 | Sun Nov 23 | at Titans | W30-24 | 8-3 | .727 | Nissan Stadium · Nashville, TN |
| 13 | Sun Nov 30 | vs Vikings | W26-0 | 9-3 | .750 | Lumen Field · Seattle, WA |
| 14 | Sun Dec 7 | at Falcons | W37-9 | 10-3 | .769 | Mercedes-Benz Stadium · Atlanta, GA |
| 15 | Sun Dec 14 | vs Colts | W18-16 | 11-3 | .786 | Lumen Field · Seattle, WA |
| 16 | Thu Dec 18 | vsRams | W38-37 (OT) | 12-3 | .800 | Lumen Field · Seattle, WA |
| 17 | Sun Dec 28 | at Panthers | W27-10 | 13-3 | .813 | Bank of America Stadium · Charlotte, NC |
| 18 | Sat Jan 3 | at49ers | W13-3 | 14-3 | .824 | Levi's® Stadium · Santa Clara, CA |
| DIV | Sat Jan 17 | vs49ers | W41-6 | 14-3 | .824 | Lumen Field · Seattle, WA |
| CONF | Sun Jan 25 | vsRams | W31-27 | 14-3 | .824 | Lumen Field · Seattle, WA |
| SB | Sun Feb 8 | at Patriots | W29-13 | 14-3 | .824 | Levi's® Stadium · Santa Clara, CA |
