| 1 | Sun Sep 7 | at Jets | W34-32 | 1-0 | 1.000 | MetLife Stadium · East Rutherford, NJ |
| 2 | Sun Sep 14 | vs Seahawks | L17-31 | 1-1 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 3 | Sun Sep 21 | at Patriots | W21-14 | 2-1 | .667 | Gillette Stadium · Foxborough, MA |
| 4 | Sun Sep 28 | vs Vikings | W24-21 | 3-1 | .750 | Croke Park · Dublin, Ireland |
| --bye week-- |
| 6 | Sun Oct 12 | vs Browns | W23-9 | 4-1 | .800 | Acrisure Stadium · Pittsburgh, PA |
| 7 | Thu Oct 16 | at Bengals | L31-33 | 4-2 | .667 | Paycor Stadium · Cincinnati, OH |
| 8 | Sun Oct 26 | vs Packers | L25-35 | 4-3 | .571 | Acrisure Stadium · Pittsburgh, PA |
| 9 | Sun Nov 2 | vs Colts | W27-20 | 5-3 | .625 | Acrisure Stadium · Pittsburgh, PA |
| 10 | Sun Nov 9 | at Chargers | L10-25 | 5-4 | .556 | SoFi Stadium · Inglewood, CA |
| 11 | Sun Nov 16 | vsBengals | W34-12 | 6-4 | .600 | Acrisure Stadium · Pittsburgh, PA |
| 12 | Sun Nov 23 | at Bears | L28-31 | 6-5 | .545 | Soldier Field · Chicago, IL |
| 13 | Sun Nov 30 | vs Bills | L7-26 | 6-6 | .500 | Acrisure Stadium · Pittsburgh, PA |
| 14 | Sun Dec 7 | at Ravens | W27-22 | 7-6 | .538 | M&T Bank Stadium · Baltimore, MD |
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