| 1 | Sun Sep 7 | at Rams | L9-14 | 0-1 | .000 | SoFi Stadium · Inglewood, CA |
| 2 | Mon Sep 15 | vs Buccaneers | L19-20 | 0-2 | .000 | NRG Stadium · Houston, TX |
| 3 | Sun Sep 21 | at Jaguars | L10-17 | 0-3 | .000 | TIAA Bank Field · Jacksonville, FL |
| 4 | Sun Sep 28 | vs Titans | W26-0 | 1-3 | .250 | NRG Stadium · Houston, TX |
| 5 | Sun Oct 5 | at Ravens | W44-10 | 2-3 | .400 | M&T Bank Stadium · Baltimore, MD |
| --bye week-- |
| 7 | Mon Oct 20 | at Seahawks | L19-27 | 2-4 | .333 | Lumen Field · Seattle, WA |
| 8 | Sun Oct 26 | vs 49ers | W26-15 | 3-4 | .429 | NRG Stadium · Houston, TX |
| 9 | Sun Nov 2 | vs Broncos | L15-18 | 3-5 | .375 | NRG Stadium · Houston, TX |
| 10 | Sun Nov 9 | vsJaguars | W36-29 | 4-5 | .444 | NRG Stadium · Houston, TX |
| 11 | Sun Nov 16 | atTitans | W16-13 | 5-5 | .500 | Nissan Stadium · Nashville, TN |
| 12 | Thu Nov 20 | vs Bills | W23-19 | 6-5 | .545 | NRG Stadium · Houston, TX |
| 13 | Sun Nov 30 | at Colts | W20-16 | 7-5 | .583 | Lucas Oil Stadium · Indianapolis, IN |
| 14 | Sun Dec 7 | at Chiefs | W20-10 | 8-5 | .615 | Arrowhead Stadium · Kansas City, MO |
| 15 | Sun Dec 14 | vs Cardinals | W40-20 | 9-5 | .643 | NRG Stadium · Houston, TX |
| 16 | Sun Dec 21 | vs Raiders | W23-21 | 10-5 | .667 | NRG Stadium · Houston, TX |
| 17 | Sat Dec 27 | at Chargers | W20-16 | 11-5 | .688 | SoFi Stadium · Inglewood, CA |
| 18 | Sun Jan 4 | vsColts | W38-30 | 12-5 | .706 | NRG Stadium · Houston, TX |
| WC | Mon Jan 12 | at Steelers | W30-6 | 12-5 | .706 | Acrisure Stadium · Pittsburgh, PA |
| DIV | Sun Jan 18 | at Patriots | L16-28 | 12-5 | .706 | Gillette Stadium · Foxborough, MA |
