| 1 | Sun Sep 7 | at Saints | W20-13 | 1-0 | 1.000 | Caesars Superdome · New Orleans, LA |
| 2 | Sun Sep 14 | vs Panthers | W27-22 | 2-0 | 1.000 | State Farm Stadium · Glendale, AZ |
| 3 | Sun Sep 21 | at 49ers | L15-16 | 2-1 | .667 | Levi's® Stadium · Santa Clara, CA |
| 4 | Thu Sep 25 | vs Seahawks | L20-23 | 2-2 | .500 | State Farm Stadium · Glendale, AZ |
| 5 | Sun Oct 5 | vs Titans | L21-22 | 2-3 | .400 | State Farm Stadium · Glendale, AZ |
| 6 | Sun Oct 12 | at Colts | L27-31 | 2-4 | .333 | Lucas Oil Stadium · Indianapolis, IN |
| 7 | Sun Oct 19 | vs Packers | L23-27 | 2-5 | .286 | State Farm Stadium · Glendale, AZ |
| --bye week-- |
| 9 | Mon Nov 3 | at Cowboys | W27-17 | 3-5 | .375 | AT&T Stadium · Arlington, TX |
| 10 | Sun Nov 9 | atSeahawks | L22-44 | 3-6 | .333 | Lumen Field · Seattle, WA |
| 11 | Sun Nov 16 | vs49ers | L22-41 | 3-7 | .300 | State Farm Stadium · Glendale, AZ |
| 12 | Sun Nov 23 | vs Jaguars | L24-27 (OT) | 3-8 | .273 | State Farm Stadium · Glendale, AZ |
| 13 | Sun Nov 30 | at Buccaneers | L17-20 | 3-9 | .250 | Raymond James Stadium · Tampa, FL |
| 14 | Sun Dec 7 | vs Rams | L17-45 | 3-10 | .231 | State Farm Stadium · Glendale, AZ |
| 15 | Sun Dec 14 | at Texans | L20-40 | 3-11 | .214 | NRG Stadium · Houston, TX |
