| 1 | Fri Sep 5 | at Chargers | L21-27 | 0-1 | .000 | Arena Corinthians · Sao Paulo, Brazil |
| 2 | Sun Sep 14 | vs Eagles | L17-20 | 0-2 | .000 | Arrowhead Stadium · Kansas City, MO |
| 3 | Sun Sep 21 | at Giants | W22-9 | 1-2 | .333 | MetLife Stadium · East Rutherford, NJ |
| 4 | Sun Sep 28 | vs Ravens | W37-20 | 2-2 | .500 | Arrowhead Stadium · Kansas City, MO |
| 5 | Mon Oct 6 | at Jaguars | L28-31 | 2-3 | .400 | TIAA Bank Field · Jacksonville, FL |
| 6 | Sun Oct 12 | vs Lions | W30-17 | 3-3 | .500 | Arrowhead Stadium · Kansas City, MO |
| 7 | Sun Oct 19 | vs Raiders | W31-0 | 4-3 | .571 | Arrowhead Stadium · Kansas City, MO |
| 8 | Mon Oct 27 | vs Commanders | W28-7 | 5-3 | .625 | Arrowhead Stadium · Kansas City, MO |
| 9 | Sun Nov 2 | at Bills | L21-28 | 5-4 | .556 | Highmark Stadium · Orchard Park, NY |
| --bye week-- |
| 11 | Sun Nov 16 | at Broncos | L19-22 | 5-5 | .500 | Empower Field at Mile High · Denver, CO |
| 12 | Sun Nov 23 | vs Colts | W23-20 (OT) | 6-5 | .545 | Arrowhead Stadium · Kansas City, MO |
| 13 | Thu Nov 27 | at Cowboys | L28-31 | 6-6 | .500 | AT&T Stadium · Arlington, TX |
| 14 | Sun Dec 7 | vs Texans | L10-20 | 6-7 | .462 | Arrowhead Stadium · Kansas City, MO |
| 15 | Sun Dec 14 | vsChargers | L13-16 | 6-8 | .429 | Arrowhead Stadium · Kansas City, MO |
