| 1 | Mon Sep 8 | vs Vikings | L24-27 | 0-1 | .000 | Soldier Field · Chicago, IL |
| 2 | Sun Sep 14 | at Lions | L21-52 | 0-2 | .000 | Ford Field · Detroit, MI |
| 3 | Sun Sep 21 | vs Cowboys | W31-14 | 1-2 | .333 | Soldier Field · Chicago, IL |
| 4 | Sun Sep 28 | at Raiders | W25-24 | 2-2 | .500 | Allegiant Stadium · Las Vegas, NV |
| --bye week-- |
| 6 | Mon Oct 13 | at Commanders | W25-24 | 3-2 | .600 | FedEx Field · North Englewood, MD |
| 7 | Sun Oct 19 | vs Saints | W26-14 | 4-2 | .667 | Soldier Field · Chicago, IL |
| 8 | Sun Oct 26 | at Ravens | L16-30 | 4-3 | .571 | M&T Bank Stadium · Baltimore, MD |
| 9 | Sun Nov 2 | at Bengals | W47-42 | 5-3 | .625 | Paycor Stadium · Cincinnati, OH |
| 10 | Sun Nov 9 | vs Giants | W24-20 | 6-3 | .667 | Soldier Field · Chicago, IL |
| 11 | Sun Nov 16 | atVikings | W19-17 | 7-3 | .700 | U.S. Bank Stadium · Minneapolis, MN |
| 12 | Sun Nov 23 | vs Steelers | W31-28 | 8-3 | .727 | Soldier Field · Chicago, IL |
| 13 | Fri Nov 28 | at Eagles | W24-15 | 9-3 | .750 | Lincoln Financial Field · Philadelphia, PA |
| 14 | Sun Dec 7 | at Packers | L21-28 | 9-4 | .692 | Lambeau Field · Green Bay, WI |
| 15 | Sun Dec 14 | vs Browns | W31-3 | 10-4 | .714 | Soldier Field · Chicago, IL |
| 16 | Sat Dec 20 | vsPackers | W22-16 (OT) | 11-4 | .733 | Soldier Field · Chicago, IL |
| 17 | Sun Dec 28 | at 49ers | L38-42 | 11-5 | .688 | Levi's® Stadium · Santa Clara, CA |
| 18 | Sun Jan 4 | vsLions | L16-19 | 11-6 | .647 | Soldier Field · Chicago, IL |
| WC | Sat Jan 10 | vsPackers | W31-27 | 11-6 | .647 | Soldier Field · Chicago, IL |
| DIV | Sun Jan 18 | vs Rams | L17-20 (OT) | 11-6 | .647 | Soldier Field · Chicago, IL |
