| 1 | Wed Oct 26 | vs Nets | W122-117 | 1-0 | 1.000 | | TD Garden · Boston, MA |
| 2 | Thu Oct 27 | at Bulls | L99-105 | 1-1 | .500 | TNT | United Center · Chicago, IL |
| 3 | Sat Oct 29 | at Hornets | W104-98 | 2-1 | .667 | | Spectrum Center · Charlotte, NC |
| 4 | Wed Nov 2 | vs Bulls | W107-100 | 3-1 | .750 | ESPN | TD Garden · Boston, MA |
| 5 | Thu Nov 3 | at Cavaliers | L122-128 | 3-2 | .600 | TNT | Rocket Mortgage FieldHouse · Cleveland, OH |
| 6 | Sun Nov 6 | vs Nuggets | L107-123 | 3-3 | .500 | | TD Garden · Boston, MA |
| 7 | Wed Nov 9 | at Wizards | L93-118 | 3-4 | .429 | | Capital One Arena · Washington, D.C. |
| 8 | Fri Nov 11 | vs Knicks | W115-87 | 4-4 | .500 | | TD Garden · Boston, MA |
| 9 | Sat Nov 12 | at Pacers | W105-99 | 5-4 | .556 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 10 | Mon Nov 14 | at Pelicans | L105-106 | 5-5 | .500 | | Smoothie King Center · New Orleans, LA |
| 11 | Wed Nov 16 | vs Mavericks | W90-83 | 6-5 | .545 | | TD Garden · Boston, MA |
| 12 | Fri Nov 18 | vs Warriors | L88-104 | 6-6 | .500 | ESPN | TD Garden · Boston, MA |
| 13 | Sat Nov 19 | at Pistons | W94-92 | 7-6 | .538 | | Little Caesars Arena · Detroit, MI |
| 14 | Mon Nov 21 | at T-wolves | W99-93 | 8-6 | .571 | | Target Center · Minneapolis, MN |
| 15 | Wed Nov 23 | at Nets | W111-92 | 9-6 | .600 | | Barclays Center · Brooklyn, NY |
| 16 | Fri Nov 25 | vs Spurs | L103-109 | 9-7 | .563 | | TD Garden · Boston, MA |
| 17 | Mon Nov 28 | at Heat | W112-104 | 10-7 | .588 | NBA TV | Kaseya Center · Miami, FL |
| 18 | Wed Nov 30 | vs Pistons | L114-121 | 10-8 | .556 | NBA TV | TD Garden · Boston, MA |
| 19 | Fri Dec 2 | vs Kings | W97-92 | 11-8 | .579 | | TD Garden · Boston, MA |
| 20 | Sat Dec 3 | at 76ers | W107-106 | 12-8 | .600 | | Wells Fargo Center · Philadelphia, PA |
| 21 | Mon Dec 5 | at Rockets | L106-107 | 12-9 | .571 | NBA TV | Toyota Center · Houston, TX |
| 22 | Wed Dec 7 | at Magic | W117-87 | 13-9 | .591 | | Amway Center · Orlando, FL |
| 23 | Fri Dec 9 | vs Raptors | L94-101 | 13-10 | .565 | | TD Garden · Boston, MA |
| 24 | Sun Dec 11 | at Thunder | L96-99 | 13-11 | .542 | | Paycom Center · Oklahoma City, OK |
| 25 | Wed Dec 14 | at Spurs | L101-108 | 13-12 | .520 | ESPN | AT&T Center · San Antonio, TX |
| 26 | Fri Dec 16 | vs Hornets | W96-88 | 14-12 | .538 | | TD Garden · Boston, MA |
| 27 | Sun Dec 18 | at Heat | W105-95 | 15-12 | .556 | | Kaseya Center · Miami, FL |
| 28 | Tue Dec 20 | at Grizzlies | W112-109 (OT) | 16-12 | .571 | | FedExForum · Memphis, TN |
| 29 | Thu Dec 22 | at Pacers | W109-102 | 17-12 | .586 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 30 | Fri Dec 23 | vs Thunder | L112-117 | 17-13 | .567 | NBA TV | TD Garden · Boston, MA |
| 31 | Sun Dec 25 | at Knicks | W119-114 | 18-13 | .581 | ESPN | Madison Square Garden · Manhattan, NY |
| 32 | Tue Dec 27 | vs Grizzlies | W113-103 | 19-13 | .594 | | TD Garden · Boston, MA |
| 33 | Thu Dec 29 | at Cavaliers | L118-124 | 19-14 | .576 | TNT | Rocket Mortgage FieldHouse · Cleveland, OH |
| 34 | Fri Dec 30 | vs Heat | W117-114 | 20-14 | .588 | | TD Garden · Boston, MA |
| 35 | Tue Jan 3 | vs Jazz | W115-104 | 21-14 | .600 | NBA TV | TD Garden · Boston, MA |
| 36 | Fri Jan 6 | vs 76ers | W110-106 | 22-14 | .611 | | TD Garden · Boston, MA |
| 37 | Sat Jan 7 | vs Pelicans | W117-108 | 23-14 | .622 | | TD Garden · Boston, MA |
| 38 | Tue Jan 10 | at Raptors | L106-114 | 23-15 | .605 | NBA TV | Scotiabank Arena · Toronto, ON |
| 39 | Wed Jan 11 | vs Wizards | W117-108 | 24-15 | .615 | | TD Garden · Boston, MA |
| 40 | Fri Jan 13 | at Hawks | W103-101 | 25-15 | .625 | ESPN | State Farm Arena · Atlanta, GA |
| 41 | Mon Jan 16 | vs Hornets | W108-98 | 26-15 | .634 | | TD Garden · Boston, MA |
| 42 | Wed Jan 18 | vs Knicks | L106-117 | 26-16 | .619 | | TD Garden · Boston, MA |
| 43 | Sat Jan 21 | vs Blazers | L123-127 (OT) | 26-17 | .605 | | TD Garden · Boston, MA |
| 44 | Tue Jan 24 | at Wizards | L108-123 | 26-18 | .591 | | Capital One Arena · Washington, D.C. |
| 45 | Wed Jan 25 | vs Rockets | W120-109 | 27-18 | .600 | | TD Garden · Boston, MA |
| 46 | Fri Jan 27 | vs Magic | W128-98 | 28-18 | .609 | | TD Garden · Boston, MA |
| 47 | Sat Jan 28 | at Bucks | W112-108 (OT) | 29-18 | .617 | | Fiserv Forum · Milwaukee, WI |
| 48 | Mon Jan 30 | vs Pistons | W113-109 | 30-18 | .625 | TNT | TD Garden · Boston, MA |
| 49 | Wed Feb 1 | vs Raptors | W109-104 | 31-18 | .633 | | TD Garden · Boston, MA |
| 50 | Fri Feb 3 | vs Lakers | W113-107 | 32-18 | .640 | ESPN | TD Garden · Boston, MA |
| 51 | Sun Feb 5 | vs Clippers | W107-102 | 33-18 | .647 | ABC | TD Garden · Boston, MA |
| 52 | Wed Feb 8 | at Kings | L92-108 | 33-19 | .635 | | Golden 1 Center · Sacramento, CA |
| 53 | Thu Feb 9 | at Blazers | W120-111 | 34-19 | .642 | TNT | Moda Center · Portland, OR |
| 54 | Sat Feb 11 | at Jazz | W112-104 | 35-19 | .648 | | Vivint Arena · Salt Lake City, UT |
| 55 | Mon Feb 13 | at Mavericks | W111-98 | 36-19 | .655 | | American Airlines Center · Dallas, TX |
| 56 | Wed Feb 15 | vs 76ers | W116-108 | 37-19 | .661 | | TD Garden · Boston, MA |
| 57 | Thu Feb 16 | at Bulls | L103-104 | 37-20 | .649 | TNT | United Center · Chicago, IL |
| 58 | Fri Feb 24 | at Raptors | L97-107 | 37-21 | .638 | ESPN | Scotiabank Arena · Toronto, ON |
| 59 | Sun Feb 26 | at Pistons | W104-98 | 38-21 | .644 | | Little Caesars Arena · Detroit, MI |
| 60 | Mon Feb 27 | vs Hawks | L98-114 | 38-22 | .633 | | TD Garden · Boston, MA |
| 61 | Wed Mar 1 | vs Cavaliers | W103-99 | 39-22 | .639 | ESPN | TD Garden · Boston, MA |
| 62 | Fri Mar 3 | at Lakers | W115-95 | 40-22 | .645 | | Crypto.com Arena · Los Angeles, CA |
| 63 | Sun Mar 5 | at Suns | L106-109 | 40-23 | .635 | | Footprint Center · Phoenix, AZ |
| 64 | Mon Mar 6 | at Clippers | L102-116 | 40-24 | .625 | TNT | Intuit Dome · Inglewood, CA |
| 65 | Wed Mar 8 | at Warriors | W99-86 | 41-24 | .631 | ESPN | Chase Center · San Francisco, CA |
| 66 | Fri Mar 10 | at Nuggets | L99-119 | 41-25 | .621 | | Ball Arena · Denver, CO |
| 67 | Sun Mar 12 | vs Bulls | W100-80 | 42-25 | .627 | ABC | TD Garden · Boston, MA |
| 68 | Wed Mar 15 | vs T-wolves | W117-104 | 43-25 | .632 | | TD Garden · Boston, MA |
| 69 | Fri Mar 17 | at Nets | W98-95 | 44-25 | .638 | | Barclays Center · Brooklyn, NY |
| 70 | Sun Mar 19 | at 76ers | L99-105 | 44-26 | .629 | | Wells Fargo Center · Philadelphia, PA |
| 71 | Mon Mar 20 | vs Wizards | W110-102 | 45-26 | .634 | | TD Garden · Boston, MA |
| 72 | Wed Mar 22 | vs Pacers | W109-100 | 46-26 | .639 | | TD Garden · Boston, MA |
| 73 | Fri Mar 24 | vs Suns | W130-120 | 47-26 | .644 | | TD Garden · Boston, MA |
| 74 | Sun Mar 26 | vs Heat | W112-108 | 48-26 | .649 | | TD Garden · Boston, MA |
| 75 | Wed Mar 29 | vs Bucks | L100-103 | 48-27 | .640 | | TD Garden · Boston, MA |
| 76 | Fri Mar 31 | vs Magic | W117-116 | 49-27 | .645 | | TD Garden · Boston, MA |
| 77 | Sun Apr 2 | at Knicks | W110-94 | 50-27 | .649 | ABC | Madison Square Garden · Manhattan, NY |
| 78 | Wed Apr 5 | vs Cavaliers | L91-114 | 50-28 | .641 | ESPN | TD Garden · Boston, MA |
| 79 | Thu Apr 6 | at Hawks | L116-123 | 50-29 | .633 | TNT | State Farm Arena · Atlanta, GA |
| 80 | Sat Apr 8 | at Hornets | W121-114 | 51-29 | .637 | | Spectrum Center · Charlotte, NC |
| 81 | Mon Apr 10 | vs Nets | W114-105 | 52-29 | .642 | | TD Garden · Boston, MA |
| 82 | Wed Apr 12 | vs Bucks | W112-94 | 53-29 | .646 | | TD Garden · Boston, MA |
| 1 | Sun Apr 16 | vs Bulls | L102-106 | 0-1 | .000 | TNT | TD Garden · Boston, MA |
| 2 | Tue Apr 18 | vs Bulls | L97-111 | 0-2 | .000 | TNT | TD Garden · Boston, MA |
| 3 | Fri Apr 21 | at Bulls | W104-87 | 1-2 | .333 | ESPN | United Center · Chicago, IL |
| 4 | Sun Apr 23 | at Bulls | W104-95 | 2-2 | .500 | TNT | United Center · Chicago, IL |
| 5 | Wed Apr 26 | vs Bulls | W108-97 | 3-2 | .600 | TNT | TD Garden · Boston, MA |
| 6 | Fri Apr 28 | at Bulls | W105-83 | 4-2 | .667 | ESPN | United Center · Chicago, IL |
| 1 | Sun Apr 30 | vs Wizards | W123-111 | 1-0 | 1.000 | ABC | TD Garden · Boston, MA |
| 2 | Tue May 2 | vs Wizards | W129-119 (OT) | 2-0 | 1.000 | TNT | TD Garden · Boston, MA |
| 3 | Thu May 4 | at Wizards | L89-116 | 2-1 | .667 | ESPN | Capital One Arena · Washington, D.C. |
| 4 | Sun May 7 | at Wizards | L102-121 | 2-2 | .500 | TNT | Capital One Arena · Washington, D.C. |
| 5 | Wed May 10 | vs Wizards | W123-101 | 3-2 | .600 | TNT | TD Garden · Boston, MA |
| 6 | Fri May 12 | at Wizards | L91-92 | 3-3 | .500 | ESPN | Capital One Arena · Washington, D.C. |
| 7 | Mon May 15 | vs Wizards | W115-105 | 4-3 | .571 | TNT | TD Garden · Boston, MA |
| 1 | Wed May 17 | vs Cavaliers | L104-117 | 0-1 | .000 | TNT | TD Garden · Boston, MA |
| 2 | Fri May 19 | vs Cavaliers | L86-130 | 0-2 | .000 | TNT | TD Garden · Boston, MA |
| 3 | Sun May 21 | at Cavaliers | W111-108 | 1-2 | .333 | TNT | Rocket Mortgage FieldHouse · Cleveland, OH |
| 4 | Tue May 23 | at Cavaliers | L99-112 | 1-3 | .250 | TNT | Rocket Mortgage FieldHouse · Cleveland, OH |
| 5 | Thu May 25 | vs Cavaliers | L102-135 | 1-4 | .200 | TNT | TD Garden · Boston, MA |