| 1 | Wed Oct 22 | at Celtics | W117-116 | 1-0 | 1.000 | | TD Garden · Boston, MA |
| 2 | Sat Oct 25 | vs Hornets | W125-121 | 2-0 | 1.000 | | Wells Fargo Center · Philadelphia, PA |
| 3 | Mon Oct 27 | vs Magic | W136-124 | 3-0 | 1.000 | | Wells Fargo Center · Philadelphia, PA |
| 4 | Tue Oct 28 | at Wizards | W139-134 (OT) | 4-0 | 1.000 | | Capital One Arena · Washington, D.C. |
| 5 | Fri Oct 31 | vs Celtics | L108-109 | 4-1 | .800 | Amazon | Wells Fargo Center · Philadelphia, PA |
| 6 | Sun Nov 2 | at Nets | W129-105 | 5-1 | .833 | | Barclays Center · Brooklyn, NY |
| 7 | Tue Nov 4 | at Bulls | L111-113 | 5-2 | .714 | | United Center · Chicago, IL |
| 8 | Wed Nov 5 | at Cavaliers | L121-132 | 5-3 | .625 | | Rocket Mortgage FieldHouse · Cleveland, OH |
| 9 | Sat Nov 8 | vs Raptors | W130-120 | 6-3 | .667 | | Wells Fargo Center · Philadelphia, PA |
| 10 | Sun Nov 9 | vs Pistons | L108-111 | 6-4 | .600 | | Wells Fargo Center · Philadelphia, PA |
| 11 | Tue Nov 11 | vs Celtics | W102-100 | 7-4 | .636 | NBC | Wells Fargo Center · Philadelphia, PA |
| 12 | Fri Nov 14 | at Pistons | L105-114 | 7-5 | .583 | | Little Caesars Arena · Detroit, MI |
| 13 | Mon Nov 17 | vs Clippers | W110-108 | 8-5 | .615 | | Wells Fargo Center · Philadelphia, PA |
| 14 | Wed Nov 19 | vs Raptors | L112-121 | 8-6 | .571 | | Wells Fargo Center · Philadelphia, PA |
| 15 | Thu Nov 20 | at Bucks | W123-114 (OT) | 9-6 | .600 | | Fiserv Forum · Milwaukee, WI |
| 16 | Sun Nov 23 | vs Heat | L117-127 | 9-7 | .563 | | Wells Fargo Center · Philadelphia, PA |
| 17 | Tue Nov 25 | vs Magic | L103-144 | 9-8 | .529 | NBC | Wells Fargo Center · Philadelphia, PA |
| 18 | Fri Nov 28 | at Nets | W115-103 | 10-8 | .556 | | Barclays Center · Brooklyn, NY |
| 19 | Sun Nov 30 | vs Hawks | L134-142 (2OT) | 10-9 | .526 | | Wells Fargo Center · Philadelphia, PA |
| 20 | Tue Dec 2 | vs Wizards | W121-102 | 11-9 | .550 | | Wells Fargo Center · Philadelphia, PA |
| 21 | Thu Dec 4 | vs Warriors | W99-98 | 12-9 | .571 | NBA TV | Wells Fargo Center · Philadelphia, PA |
| 22 | Fri Dec 5 | at Bucks | W116-101 | 13-9 | .591 | | Fiserv Forum · Milwaukee, WI |
| 23 | Sun Dec 7 | vs Lakers | L108-112 | 13-10 | .565 | | Wells Fargo Center · Philadelphia, PA |
| 24 | Fri Dec 12 | vs Pacers | W115-105 | 14-10 | .583 | | Wells Fargo Center · Philadelphia, PA |
| 25 | Sun Dec 14 | at Hawks | L117-120 | 14-11 | .560 | | State Farm Arena · Atlanta, GA |
| 26 | Fri Dec 19 | at Knicks | W116-107 | 15-11 | .577 | Amazon | Madison Square Garden · Manhattan, NY |
| 27 | Sat Dec 20 | vs Mavericks | W121-114 | 16-11 | .593 | | Wells Fargo Center · Philadelphia, PA |
| 28 | Tue Dec 23 | vs Nets | L106-114 | 16-12 | .571 | | Wells Fargo Center · Philadelphia, PA |
| 29 | Fri Dec 26 | at Bulls | L102-109 | 16-13 | .552 | Amazon | United Center · Chicago, IL |
| 30 | Sun Dec 28 | at Thunder | L104-129 | 16-14 | .533 | | Paycom Center · Oklahoma City, OK |
| 31 | Tue Dec 30 | at Grizzlies | W139-136 (OT) | 17-14 | .548 | NBC | FedExForum · Memphis, TN |
| 32 | Thu Jan 1 | at Mavericks | W123-108 | 18-14 | .563 | NBA TV | American Airlines Center · Dallas, TX |
| 33 | Sat Jan 3 | at Knicks | W130-119 | 19-14 | .576 | NBA TV | Madison Square Garden · Manhattan, NY |
| 34 | Mon Jan 5 | vs Nuggets | L124-125 (OT) | 19-15 | .559 | Peacock | Wells Fargo Center · Philadelphia, PA |
| 35 | Wed Jan 7 | vs Wizards | W131-110 | 20-15 | .571 | | Wells Fargo Center · Philadelphia, PA |
| 36 | Fri Jan 9 | at Magic | W103-91 | 21-15 | .583 | | Kia Center · Orlando, FL |
| 37 | Sun Jan 11 | at Raptors | L115-116 (OT) | 21-16 | .568 | | Scotiabank Arena · Toronto, ON |
| 38 | Mon Jan 12 | at Raptors | W115-102 | 22-16 | .579 | | Scotiabank Arena · Toronto, ON |
| 39 | Wed Jan 14 | vs Cavaliers | L107-133 | 22-17 | .564 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 40 | Fri Jan 16 | vs Cavaliers | L115-117 | 22-18 | .550 | ESPN | Wells Fargo Center · Philadelphia, PA |
| 41 | Mon Jan 19 | vs Pacers | W113-104 | 23-18 | .561 | | Wells Fargo Center · Philadelphia, PA |
| 42 | Tue Jan 20 | vs Suns | L110-116 | 23-19 | .548 | | Wells Fargo Center · Philadelphia, PA |
| 43 | Thu Jan 22 | vs Rockets | W128-122 (OT) | 24-19 | .558 | | Wells Fargo Center · Philadelphia, PA |
| 44 | Sat Jan 24 | vs Knicks | L109-112 | 24-20 | .545 | ABC | Wells Fargo Center · Philadelphia, PA |
| 45 | Mon Jan 26 | at Hornets | L93-130 | 24-21 | .533 | | Spectrum Center · Charlotte, NC |
| 46 | Tue Jan 27 | vs Bucks | W139-122 | 25-21 | .543 | NBC | Wells Fargo Center · Philadelphia, PA |
| 47 | Thu Jan 29 | vs Kings | W113-111 | 26-21 | .553 | | Wells Fargo Center · Philadelphia, PA |
| 48 | Sat Jan 31 | vs Pelicans | W124-114 | 27-21 | .563 | | Wells Fargo Center · Philadelphia, PA |
| 49 | Mon Feb 2 | at Clippers | W128-113 | 28-21 | .571 | Peacock | Intuit Dome · Inglewood, CA |
| 50 | Tue Feb 3 | at Warriors | W113-94 | 29-21 | .580 | | Chase Center · San Francisco, CA |
| 51 | Thu Feb 5 | at Lakers | L115-119 | 29-22 | .569 | | Crypto.com Arena · Los Angeles, CA |
| 52 | Sat Feb 7 | at Suns | W109-103 | 30-22 | .577 | | Mortgage Matchup Center · Phoenix, AZ |
| 53 | Mon Feb 9 | at Blazers | L118-135 | 30-23 | .566 | | Moda Center · Portland, OR |