| 1 | Tue Oct 21 | vs Warriors | L109-119 | 0-1 | .000 | NBC | Crypto.com Arena · Los Angeles, CA |
| 2 | Fri Oct 24 | vs T-wolves | W128-110 | 1-1 | .500 | Amazon | Crypto.com Arena · Los Angeles, CA |
| 3 | Sun Oct 26 | at Kings | W127-120 | 2-1 | .667 | | Golden 1 Center · Sacramento, CA |
| 4 | Mon Oct 27 | vs Blazers | L108-122 | 2-2 | .500 | | Crypto.com Arena · Los Angeles, CA |
| 5 | Wed Oct 29 | at T-wolves | W116-115 | 3-2 | .600 | ESPN | Target Center · Minneapolis, MN |
| 6 | Fri Oct 31 | at Grizzlies | W117-112 | 4-2 | .667 | Amazon | FedExForum · Memphis, TN |
| 7 | Sun Nov 2 | vs Heat | W130-120 | 5-2 | .714 | | Crypto.com Arena · Los Angeles, CA |
| 8 | Mon Nov 3 | at Blazers | W123-115 | 6-2 | .750 | NBA TV | Moda Center · Portland, OR |
| 9 | Wed Nov 5 | vs Spurs | W118-116 | 7-2 | .778 | ESPN | Crypto.com Arena · Los Angeles, CA |
| 10 | Sat Nov 8 | at Hawks | L102-122 | 7-3 | .700 | NBA TV | State Farm Arena · Atlanta, GA |
| 11 | Mon Nov 10 | at Hornets | W121-111 | 8-3 | .727 | | Spectrum Center · Charlotte, NC |
| 12 | Wed Nov 12 | at Thunder | L92-121 | 8-4 | .667 | ESPN | Paycom Center · Oklahoma City, OK |
| 13 | Fri Nov 14 | at Pelicans | W118-104 | 9-4 | .692 | | Smoothie King Center · New Orleans, LA |
| 14 | Sat Nov 15 | at Bucks | W119-95 | 10-4 | .714 | NBA TV | Fiserv Forum · Milwaukee, WI |
| 15 | Tue Nov 18 | vs Jazz | W140-126 | 11-4 | .733 | | Crypto.com Arena · Los Angeles, CA |
| 16 | Sun Nov 23 | at Jazz | W108-106 | 12-4 | .750 | | Vivint Arena · Salt Lake City, UT |
| 17 | Tue Nov 25 | vs Clippers | W135-118 | 13-4 | .765 | NBC | Crypto.com Arena · Los Angeles, CA |
| 18 | Fri Nov 28 | vs Mavericks | W129-119 | 14-4 | .778 | Amazon | Crypto.com Arena · Los Angeles, CA |
| 19 | Sun Nov 30 | vs Pelicans | W133-121 | 15-4 | .789 | | Crypto.com Arena · Los Angeles, CA |
| 20 | Mon Dec 1 | vs Suns | L108-125 | 15-5 | .750 | Peacock | Crypto.com Arena · Los Angeles, CA |
| 21 | Thu Dec 4 | at Raptors | W123-120 | 16-5 | .762 | | Scotiabank Arena · Toronto, ON |
| 22 | Fri Dec 5 | at Celtics | L105-126 | 16-6 | .727 | Amazon | TD Garden · Boston, MA |
| 23 | Sun Dec 7 | at 76ers | W112-108 | 17-6 | .739 | | Wells Fargo Center · Philadelphia, PA |
| 24 | Wed Dec 10 | vs Spurs | L119-132 | 17-7 | .708 | Amazon | Crypto.com Arena · Los Angeles, CA |
| 25 | Sun Dec 14 | at Suns | W116-114 | 18-7 | .720 | | Mortgage Matchup Center · Phoenix, AZ |
| 26 | Thu Dec 18 | at Jazz | W143-135 | 19-7 | .731 | | Vivint Arena · Salt Lake City, UT |
| 27 | Sat Dec 20 | at Clippers | L88-103 | 19-8 | .704 | NBA TV | Intuit Dome · Inglewood, CA |
| 28 | Tue Dec 23 | at Suns | L108-132 | 19-9 | .679 | | Mortgage Matchup Center · Phoenix, AZ |
| 29 | Thu Dec 25 | vs Rockets | L96-119 | 19-10 | .655 | ABC | Crypto.com Arena · Los Angeles, CA |
| 30 | Sun Dec 28 | vs Kings | W125-101 | 20-10 | .667 | | Crypto.com Arena · Los Angeles, CA |
| 31 | Tue Dec 30 | vs Pistons | L106-128 | 20-11 | .645 | NBC | Crypto.com Arena · Los Angeles, CA |
| 32 | Fri Jan 2 | vs Grizzlies | W128-121 | 21-11 | .656 | | Crypto.com Arena · Los Angeles, CA |
| 33 | Sun Jan 4 | vs Grizzlies | W120-114 | 22-11 | .667 | | Crypto.com Arena · Los Angeles, CA |
| 34 | Tue Jan 6 | at Pelicans | W111-103 | 23-11 | .676 | | Smoothie King Center · New Orleans, LA |
| 35 | Wed Jan 7 | at Spurs | L91-107 | 23-12 | .657 | ESPN | AT&T Center · San Antonio, TX |
| 36 | Fri Jan 9 | vs Bucks | L101-105 | 23-13 | .639 | NBA TV | Crypto.com Arena · Los Angeles, CA |
| 37 | Mon Jan 12 | at Kings | L112-124 | 23-14 | .622 | | Golden 1 Center · Sacramento, CA |
| 38 | Tue Jan 13 | vs Hawks | W141-116 | 24-14 | .632 | | Crypto.com Arena · Los Angeles, CA |
| 39 | Thu Jan 15 | vs Hornets | L117-135 | 24-15 | .615 | | Crypto.com Arena · Los Angeles, CA |
| 40 | Sat Jan 17 | at Blazers | L116-132 | 24-16 | .600 | NBA TV | Moda Center · Portland, OR |
| 41 | Sun Jan 18 | vs Raptors | W110-93 | 25-16 | .610 | | Crypto.com Arena · Los Angeles, CA |
| 42 | Tue Jan 20 | at Nuggets | W115-107 | 26-16 | .619 | NBC | Ball Arena · Denver, CO |
| 43 | Thu Jan 22 | at Clippers | L104-112 | 26-17 | .605 | Amazon | Intuit Dome · Inglewood, CA |
| 44 | Sat Jan 24 | at Mavericks | W116-110 | 27-17 | .614 | ABC | American Airlines Center · Dallas, TX |
| 45 | Mon Jan 26 | at Bulls | W129-118 | 28-17 | .622 | | United Center · Chicago, IL |
| 46 | Wed Jan 28 | at Cavaliers | L99-129 | 28-18 | .609 | ESPN | Rocket Mortgage FieldHouse · Cleveland, OH |
| 47 | Fri Jan 30 | at Wizards | W142-111 | 29-18 | .617 | | Capital One Arena · Washington, D.C. |
| 48 | Sun Feb 1 | at Knicks | L100-112 | 29-19 | .604 | Telemundo | Madison Square Garden · Manhattan, NY |
| 49 | Tue Feb 3 | at Nets | W125-109 | 30-19 | .612 | | Barclays Center · Brooklyn, NY |
| 50 | Thu Feb 5 | vs 76ers | W119-115 | 31-19 | .620 | | Crypto.com Arena · Los Angeles, CA |
| 51 | Sat Feb 7 | vs Warriors | W105-99 | 32-19 | .627 | ABC | Crypto.com Arena · Los Angeles, CA |
| 52 | Mon Feb 9 | vs Thunder | L110-119 | 32-20 | .615 | Peacock | Crypto.com Arena · Los Angeles, CA |