| 1 | Wed Oct 22 | vs Cavaliers | W119-111 | 1-0 | 1.000 | ESPN | Madison Square Garden · Manhattan, NY |
| 2 | Fri Oct 24 | vs Celtics | W105-95 | 2-0 | 1.000 | Amazon | Madison Square Garden · Manhattan, NY |
| 3 | Sun Oct 26 | at Heat | L107-115 | 2-1 | .667 | | Kaseya Center · Miami, FL |
| 4 | Tue Oct 28 | at Bucks | L111-121 | 2-2 | .500 | NBC | Fiserv Forum · Milwaukee, WI |
| 5 | Fri Oct 31 | at Bulls | L125-135 | 2-3 | .400 | | United Center · Chicago, IL |
| 6 | Sun Nov 2 | vs Bulls | W128-116 | 3-3 | .500 | | Madison Square Garden · Manhattan, NY |
| 7 | Mon Nov 3 | vs Wizards | W119-102 | 4-3 | .571 | | Madison Square Garden · Manhattan, NY |
| 8 | Wed Nov 5 | vs T-wolves | W137-114 | 5-3 | .625 | ESPN | Madison Square Garden · Manhattan, NY |
| 9 | Sun Nov 9 | vs Nets | W134-98 | 6-3 | .667 | | Madison Square Garden · Manhattan, NY |
| 10 | Tue Nov 11 | vs Grizzlies | W133-120 | 7-3 | .700 | | Madison Square Garden · Manhattan, NY |
| 11 | Wed Nov 12 | vs Magic | L107-124 | 7-4 | .636 | ESPN | Madison Square Garden · Manhattan, NY |
| 12 | Fri Nov 14 | vs Heat | W140-132 | 8-4 | .667 | Amazon | Madison Square Garden · Manhattan, NY |
| 13 | Mon Nov 17 | at Heat | L113-115 | 8-5 | .615 | | Kaseya Center · Miami, FL |
| 14 | Wed Nov 19 | at Mavericks | W113-111 | 9-5 | .643 | ESPN | American Airlines Center · Dallas, TX |
| 15 | Sat Nov 22 | at Magic | L121-133 | 9-6 | .600 | NBA TV | Kia Center · Orlando, FL |
| 16 | Mon Nov 24 | at Nets | W113-100 | 10-6 | .625 | | Barclays Center · Brooklyn, NY |
| 17 | Wed Nov 26 | at Hornets | W129-101 | 11-6 | .647 | | Spectrum Center · Charlotte, NC |
| 18 | Fri Nov 28 | vs Bucks | W118-109 | 12-6 | .667 | Amazon | Madison Square Garden · Manhattan, NY |
| 19 | Sun Nov 30 | vs Raptors | W116-94 | 13-6 | .684 | | Madison Square Garden · Manhattan, NY |
| 20 | Tue Dec 2 | at Celtics | L117-123 | 13-7 | .650 | NBC | TD Garden · Boston, MA |
| 21 | Wed Dec 3 | vs Hornets | W119-104 | 14-7 | .667 | | Madison Square Garden · Manhattan, NY |
| 22 | Fri Dec 5 | vs Jazz | W146-112 | 15-7 | .682 | | Madison Square Garden · Manhattan, NY |
| 23 | Sun Dec 7 | vs Magic | W106-100 | 16-7 | .696 | | Madison Square Garden · Manhattan, NY |
| 24 | Tue Dec 9 | at Raptors | W117-101 | 17-7 | .708 | Amazon | Scotiabank Arena · Toronto, ON |
| 25 | Sat Dec 13 | at Magic | W132-120 | 18-7 | .720 | Amazon | Kia Center · Orlando, FL |
| 26 | Tue Dec 16 | vs Spurs | W124-113 | 1-0 | 1.000 | Amazon | Madison Square Garden · Manhattan, NY |
| 27 | Thu Dec 18 | at Pacers | W114-113 | 19-7 | .731 | | Gainbridge Fieldhouse · Indianapolis, IN |
| 28 | Fri Dec 19 | vs 76ers | L107-116 | 19-8 | .704 | Amazon | Madison Square Garden · Manhattan, NY |
| 29 | Sun Dec 21 | vs Heat | W132-125 | 20-8 | .714 | | Madison Square Garden · Manhattan, NY |
| 30 | Tue Dec 23 | at T-wolves | L104-115 | 20-9 | .690 | | Target Center · Minneapolis, MN |
| 31 | Thu Dec 25 | vs Cavaliers | W126-124 | 21-9 | .700 | ABC | Madison Square Garden · Manhattan, NY |
| 32 | Sat Dec 27 | at Hawks | W128-125 | 22-9 | .710 | NBA TV | State Farm Arena · Atlanta, GA |
| 33 | Mon Dec 29 | at Pelicans | W130-125 | 23-9 | .719 | | Smoothie King Center · New Orleans, LA |
| 34 | Wed Dec 31 | at Spurs | L132-134 | 23-10 | .697 | NBA TV | AT&T Center · San Antonio, TX |
| 35 | Fri Jan 2 | vs Hawks | L99-111 | 23-11 | .676 | | Madison Square Garden · Manhattan, NY |
| 36 | Sat Jan 3 | vs 76ers | L119-130 | 23-12 | .657 | NBA TV | Madison Square Garden · Manhattan, NY |
| 37 | Mon Jan 5 | at Pistons | L90-121 | 23-13 | .639 | Peacock | Little Caesars Arena · Detroit, MI |
| 38 | Wed Jan 7 | vs Clippers | W123-111 | 24-13 | .649 | | Madison Square Garden · Manhattan, NY |
| 39 | Fri Jan 9 | at Suns | L107-112 | 24-14 | .632 | | Mortgage Matchup Center · Phoenix, AZ |
| 40 | Sun Jan 11 | at Blazers | W123-114 | 25-14 | .641 | | Moda Center · Portland, OR |
| 41 | Wed Jan 14 | at Kings | L101-112 | 25-15 | .625 | | Golden 1 Center · Sacramento, CA |
| 42 | Thu Jan 15 | at Warriors | L113-126 | 25-16 | .610 | Amazon | Chase Center · San Francisco, CA |
| 43 | Sat Jan 17 | vs Suns | L99-106 | 25-17 | .595 | NBA TV | Madison Square Garden · Manhattan, NY |
| 44 | Mon Jan 19 | vs Mavericks | L97-114 | 25-18 | .581 | NBC | Madison Square Garden · Manhattan, NY |
| 45 | Wed Jan 21 | vs Nets | W120-66 | 26-18 | .591 | | Madison Square Garden · Manhattan, NY |
| 46 | Sat Jan 24 | at 76ers | W112-109 | 27-18 | .600 | ABC | Wells Fargo Center · Philadelphia, PA |
| 47 | Tue Jan 27 | vs Kings | W103-87 | 28-18 | .609 | | Madison Square Garden · Manhattan, NY |
| 48 | Wed Jan 28 | at Raptors | W119-92 | 29-18 | .617 | | Scotiabank Arena · Toronto, ON |
| 49 | Fri Jan 30 | vs Blazers | W127-97 | 30-18 | .625 | | Madison Square Garden · Manhattan, NY |
| 50 | Sun Feb 1 | vs Lakers | W112-100 | 31-18 | .633 | Telemundo | Madison Square Garden · Manhattan, NY |
| 51 | Tue Feb 3 | at Wizards | W132-101 | 32-18 | .640 | | Capital One Arena · Washington, D.C. |
| 52 | Wed Feb 4 | vs Nuggets | W134-127 (2OT) | 33-18 | .647 | ESPN | Madison Square Garden · Manhattan, NY |
| 53 | Fri Feb 6 | at Pistons | L80-118 | 33-19 | .635 | Amazon | Little Caesars Arena · Detroit, MI |