| 1 | Mon Nov 3 | vs Bryant | W82-66 | 1-0 | 1.000 | - | ESPN+ | MVP Arena · Albany, NY |
| 2 | Fri Nov 7 | at Brown | W62-46 | 2-0 | 1.000 | - | ESPN+ | Pizzitola Sports Center · Providence, RI |
| 3 | Wed Nov 12 | at St Bonaventure | L66-75 | 2-1 | .667 | - | ESPN+ | Reilly Center · Saint Bonaventure, NY |
| 4 | Mon Nov 17 | vs Colgate | L69-72 | 2-2 | .500 | - | ESPN+ | MVP Arena · Albany, NY |
| 5 | Fri Nov 21 | vs Albany | W73-63 | 3-2 | .600 | - | ESPN+ | MVP Arena · Albany, NY |
| 6 | Mon Nov 24 | at Holy Cross | W73-69 | 4-2 | .667 | - | ESPN+ | Hart Center · Worcester, MA |
| 7 | Fri Nov 28 | vs Longwood | W70-63 | 5-2 | .714 | - | | Bender Arena · Washington, D.C. |
| 8 | Sat Nov 29 | at American | W59-55 | 6-2 | .750 | - | ESPN+ | Bender Arena · Washington, D.C. |
| 9 | Sun Nov 30 | at Maine | W64-60 | 7-2 | .778 | - | | Bender Arena · Washington, D.C. |
| 10 | Fri Dec 5 | vs Niagara | W83-54 | 8-2 | .800 | - | ESPN+ | MVP Arena · Albany, NY |
| 11 | Sun Dec 7 | vs Canisius | W74-52 | 9-2 | .818 | - | ESPN+ | MVP Arena · Albany, NY |
| 12 | Wed Dec 17 | at Vermont | L69-83 | 9-3 | .750 | - | ESPN+ | Patrick Gymnasium · Burlington, VT |
| 13 | Mon Dec 22 | at Indiana | L60-81 | 9-4 | .692 | - | BTN | Simon Skjodt Assembly Hall · Bloomington, IN |
| 14 | Fri Jan 2 | at Iona | L72-75 | 9-5 | .643 | - | ESPN+ | Hynes Athletics Center · New Rochelle, NY |
| 15 | Sun Jan 4 | at Rider | W74-65 | 10-5 | .667 | - | ESPN+ | Alumni Gymnasium (Rider) · Lawrenceville, NJ |
| 16 | Fri Jan 9 | vs Merrimack | L59-63 | 10-6 | .625 | - | ESPN+ | MVP Arena · Albany, NY |
| 17 | Sun Jan 11 | at Mount St Mary | W67-50 | 11-6 | .647 | - | ESPN+ | Knott Arena · Emmitsburg, MD |
| 18 | Wed Jan 14 | vs Sacred Heart | L80-86 | 11-7 | .611 | - | ESPN+ | MVP Arena · Albany, NY |
| 19 | Sat Jan 17 | at Manhattan | W74-59 | 12-7 | .632 | - | ESPN+ | Draddy Gymnasium · Riverdale, NY |
| 20 | Mon Jan 19 | vs Fairfield | W85-77 | 13-7 | .650 | - | ESPN+ | MVP Arena · Albany, NY |
| 21 | Thu Jan 22 | vs Marist | W69-50 | 14-7 | .667 | - | ESPN+ | MVP Arena · Albany, NY |
| 22 | Fri Jan 30 | atNiagara | W82-79 | 15-7 | .682 | - | ESPN+ | Gallagher Center · Niagara Falls, NY |
| 23 | Sun Feb 1 | atCanisius | W78-63 | 16-7 | .696 | - | ESPN+ | Koessler Athletic Center · Buffalo, NY |
| 24 | Thu Feb 5 | vsIona | W79-72 | 17-7 | .708 | - | ESPNU | MVP Arena · Albany, NY |
| 25 | Sat Feb 7 | at Saint Peter's | L65-70 | 17-8 | .680 | - | ESPN+ | Yanitelli Center · Jersey City, NJ |
Quinnipiac