| Sat Feb 21 | vs Atlanta | 1:45 PM | 5-13-16 | 28 PTS | TQL Stadium · Cincinnati, OH |
| Sat Feb 28 | at Minnesota | 1:30 PM | 16-10-8 | 58 PTS | Allianz Field · Saint Paul, MN |
| Sun Mar 8 | vs Toronto | 4:00 PM | 6-14-14 | 32 PTS | TQL Stadium · Cincinnati, OH |
| Sun Mar 15 | at New England | 11:30 AM | 9-9-16 | 36 PTS | Gillette Stadium · Foxborough, MA |
| Sun Mar 22 | vs Montreal | 10:00 AM | 6-10-18 | 28 PTS | TQL Stadium · Cincinnati, OH |
| Sat Apr 4 | at New York | 4:30 PM | 12-7-15 | 43 PTS | Sports Illustrated Stadium · Harrison, NJ |
| Sat Apr 11 | atToronto | 10:00 AM | 6-14-14 | 32 PTS | BMO Field · Toronto, ON |
| Sat Apr 18 | vs Chicago | 4:30 PM | 15-8-11 | 53 PTS | TQL Stadium · Cincinnati, OH |
| Wed Apr 22 | at NYCFC | 4:30 PM | 17-5-12 | 56 PTS | Yankee Stadium · New York City, NY |
| Sat Apr 25 | vsNew York | 4:30 PM | 12-7-15 | 43 PTS | TQL Stadium · Cincinnati, OH |
| Sat May 2 | atChicago | 5:30 PM | 15-8-11 | 53 PTS | Soldier Field · Chicago, IL |
| Sat May 9 | at Charlotte | 4:30 PM | 19-2-13 | 59 PTS | Bank of America Stadium · Charlotte, NC |
| Wed May 13 | vs Miami | 4:30 PM | 19-8-7 | 65 PTS | TQL Stadium · Cincinnati, OH |
| Sat May 16 | at San Diego | 7:30 PM | 19-6-9 | 63 PTS | Snapdragon Stadium · San Diego, CA |
| Sat May 23 | vs Orlando | 4:30 PM | 14-11-9 | 53 PTS | TQL Stadium · Cincinnati, OH |
| Wed Jul 22 | vs Vancouver | 4:30 PM | 18-9-7 | 63 PTS | TQL Stadium · Cincinnati, OH |
| Sat Jul 25 | at Columbus | 4:00 PM | 14-12-8 | 54 PTS | Lower.com Field · Columbus, OH |
| Sat Aug 1 | vs San Jose | 4:30 PM | 11-8-15 | 41 PTS | TQL Stadium · Cincinnati, OH |
| Sat Aug 15 | atOrlando | 4:30 PM | 14-11-9 | 53 PTS | Inter&Co Stadium · Orlando, FL |
| Wed Aug 19 | vsNYCFC | 4:30 PM | 17-5-12 | 56 PTS | TQL Stadium · Cincinnati, OH |
| Sat Aug 22 | vs Seattle | 4:30 PM | 15-10-9 | 55 PTS | TQL Stadium · Cincinnati, OH |
| Sat Aug 29 | at Nashville | 5:30 PM | 16-6-12 | 54 PTS | GEODIS Park · Nashville, TN |
| Sat Sep 5 | vs D.C. United | 4:30 PM | 5-11-18 | 26 PTS | TQL Stadium · Cincinnati, OH |
| Wed Sep 9 | at Philadelphia | 4:30 PM | 20-6-8 | 66 PTS | Subaru Park · Chester, PA |
| Sat Sep 12 | vsCharlotte | 4:30 PM | 19-2-13 | 59 PTS | TQL Stadium · Cincinnati, OH |
| Sat Sep 19 | at Houston | 5:30 PM | 9-10-15 | 37 PTS | Shell Energy Stadium · Houston, TX |
| Sat Sep 26 | atMontreal | 4:30 PM | 6-10-18 | 28 PTS | Stade Saputo · Montreal, QC |
| Sat Oct 10 | atAtlanta | 4:30 PM | 5-13-16 | 28 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| Wed Oct 14 | vsNew England | 4:30 PM | 9-9-16 | 36 PTS | TQL Stadium · Cincinnati, OH |
| Sun Oct 18 | vsColumbus | 4:00 PM | 14-12-8 | 54 PTS | TQL Stadium · Cincinnati, OH |
| Sat Oct 24 | atD.C. United | 4:30 PM | 5-11-18 | 26 PTS | Audi Field · Washington, D.C. |
| Wed Oct 28 | atMiami | 4:30 PM | 19-8-7 | 65 PTS | Chase Stadium · Fort Lauderdale, FL |
| Sat Oct 31 | vsPhiladelphia | 11:00 AM | 20-6-8 | 66 PTS | TQL Stadium · Cincinnati, OH |
| Sat Nov 7 | vsNashville | 1:00 PM | 16-6-12 | 54 PTS | TQL Stadium · Cincinnati, OH |
