| Sat Feb 21 | at Portland | 7:30 PM | 11-11-12 | 44 PTS | Providence Park · Portland, OR |
| Sat Feb 28 | at Kansas City | 5:30 PM | 7-7-20 | 28 PTS | Children's Mercy Park · Kansas City, KS |
| Sat Mar 7 | vs Chicago | 4:30 PM | 15-8-11 | 53 PTS | Lower.com Field · Columbus, OH |
| Sat Mar 14 | vs Nashville | 3:15 PM | 16-6-12 | 54 PTS | Lower.com Field · Columbus, OH |
| Sat Mar 21 | at Toronto | 10:00 AM | 6-14-14 | 32 PTS | BMO Field · Toronto, ON |
| Sat Apr 4 | at Atlanta | 4:30 PM | 5-13-16 | 28 PTS | Mercedes-Benz Stadium · Atlanta, GA |
| Sun Apr 12 | vs Orlando | 4:00 PM | 14-11-9 | 53 PTS | Lower.com Field · Columbus, OH |
| Sat Apr 18 | at New England | 4:30 PM | 9-9-16 | 36 PTS | Gillette Stadium · Foxborough, MA |
| Wed Apr 22 | vs LA Galaxy | 4:30 PM | 7-9-18 | 30 PTS | Lower.com Field · Columbus, OH |
| Sat Apr 25 | vs Philadelphia | 4:30 PM | 20-6-8 | 66 PTS | Lower.com Field · Columbus, OH |
| Sat May 2 | vs Minnesota | 4:30 PM | 16-10-8 | 58 PTS | Lower.com Field · Columbus, OH |
| Sun May 10 | at NYCFC | 1:30 PM | 17-5-12 | 56 PTS | Yankee Stadium · New York City, NY |
| Wed May 13 | at New York | 4:30 PM | 12-7-15 | 43 PTS | Sports Illustrated Stadium · Harrison, NJ |
| Sat May 16 | atPhiladelphia | 4:30 PM | 20-6-8 | 66 PTS | Subaru Park · Chester, PA |
| Sun May 24 | vsAtlanta | 2:00 PM | 5-13-16 | 28 PTS | Lower.com Field · Columbus, OH |
| Wed Jul 22 | vsNYCFC | 4:30 PM | 17-5-12 | 56 PTS | Lower.com Field · Columbus, OH |
| Sat Jul 25 | vs Cincinnati | 4:00 PM | 20-5-9 | 65 PTS | Lower.com Field · Columbus, OH |
| Sat Aug 1 | at Miami | 4:30 PM | 19-8-7 | 65 PTS | Chase Stadium · Fort Lauderdale, FL |
| Sat Aug 15 | at Charlotte | 4:30 PM | 19-2-13 | 59 PTS | Bank of America Stadium · Charlotte, NC |
| Wed Aug 19 | vs Montreal | 4:30 PM | 6-10-18 | 28 PTS | Lower.com Field · Columbus, OH |
| Sat Aug 22 | atNashville | 5:30 PM | 16-6-12 | 54 PTS | GEODIS Park · Nashville, TN |
| Sat Aug 29 | vsNew England | 4:30 PM | 9-9-16 | 36 PTS | Lower.com Field · Columbus, OH |
| Sat Sep 5 | vs Colorado | 4:30 PM | 11-8-15 | 41 PTS | Lower.com Field · Columbus, OH |
| Wed Sep 9 | at D.C. United | 4:30 PM | 5-11-18 | 26 PTS | Audi Field · Washington, D.C. |
| Sat Sep 12 | vsNew York | 4:30 PM | 12-7-15 | 43 PTS | Lower.com Field · Columbus, OH |
| Sat Sep 19 | atMontreal | 4:30 PM | 6-10-18 | 28 PTS | Stade Saputo · Montreal, QC |
| Sun Sep 27 | vsMiami | 4:00 PM | 19-8-7 | 65 PTS | Lower.com Field · Columbus, OH |
| Sat Oct 10 | atOrlando | 4:30 PM | 14-11-9 | 53 PTS | Inter&Co Stadium · Orlando, FL |
| Wed Oct 14 | vsCharlotte | 4:30 PM | 19-2-13 | 59 PTS | Lower.com Field · Columbus, OH |
| Sun Oct 18 | atCincinnati | 4:00 PM | 20-5-9 | 65 PTS | TQL Stadium · Cincinnati, OH |
| Sat Oct 24 | vsToronto | 11:30 AM | 6-14-14 | 32 PTS | Lower.com Field · Columbus, OH |
| Wed Oct 28 | at Dallas | 5:30 PM | 11-11-12 | 44 PTS | Toyota Stadium · Frisco, TX |
| Sat Oct 31 | vsD.C. United | 11:00 AM | 5-11-18 | 26 PTS | Lower.com Field · Columbus, OH |
| Sat Nov 7 | atChicago | 1:00 PM | 15-8-11 | 53 PTS | Soldier Field · Chicago, IL |
