| Sat Feb 21 | vs Chicago | 5:30 PM | 15-8-11 | 53 PTS | Shell Energy Stadium · Houston, TX |
| Sat Feb 28 | vs LAFC | 5:30 PM | 17-9-8 | 60 PTS | Shell Energy Stadium · Houston, TX |
| Sat Mar 7 | at New England | 11:30 AM | 9-9-16 | 36 PTS | Gillette Stadium · Foxborough, MA |
| Sat Mar 14 | vs Portland | 5:30 PM | 11-11-12 | 44 PTS | Shell Energy Stadium · Houston, TX |
| Sat Mar 21 | at Dallas | 5:30 PM | 11-11-12 | 44 PTS | Toyota Stadium · Frisco, TX |
| Sat Apr 4 | vs Seattle | 5:30 PM | 15-10-9 | 55 PTS | Shell Energy Stadium · Houston, TX |
| Sat Apr 11 | at Colorado | 6:30 PM | 11-8-15 | 41 PTS | Dick's Sporting Goods Park · Commerce City, CO |
| Sat Apr 18 | at Orlando | 4:30 PM | 14-11-9 | 53 PTS | Inter&Co Stadium · Orlando, FL |
| Wed Apr 22 | vs San Diego | 5:30 PM | 19-6-9 | 63 PTS | Shell Energy Stadium · Houston, TX |
| Sat Apr 25 | at Austin | 5:30 PM | 13-8-13 | 47 PTS | Q2 Stadium · Austin, TX |
| Sat May 2 | vsColorado | 5:30 PM | 11-8-15 | 41 PTS | Shell Energy Stadium · Houston, TX |
| Sun May 10 | atLAFC | 6:00 PM | 17-9-8 | 60 PTS | BMO Stadium · Los Angeles, CA |
| Wed May 13 | at Salt Lake | 6:30 PM | 12-5-17 | 41 PTS | America First Field · Sandy, UT |
| Sat May 16 | vs Vancouver | 5:30 PM | 18-9-7 | 63 PTS | Shell Energy Stadium · Houston, TX |
| Sat May 23 | at LA Galaxy | 7:30 PM | 7-9-18 | 30 PTS | Dignity Health Sports Park · Carson, CA |
| Wed Jul 22 | vs D.C. United | 5:30 PM | 5-11-18 | 26 PTS | Shell Energy Stadium · Houston, TX |
| Sat Jul 25 | vsAustin | 5:30 PM | 13-8-13 | 47 PTS | Shell Energy Stadium · Houston, TX |
| Sat Aug 1 | at Kansas City | 5:30 PM | 7-7-20 | 28 PTS | Children's Mercy Park · Kansas City, KS |
| Sat Aug 15 | vsLA Galaxy | 5:30 PM | 7-9-18 | 30 PTS | Shell Energy Stadium · Houston, TX |
| Wed Aug 19 | atVancouver | 7:30 PM | 18-9-7 | 63 PTS | BC Place · Vancouver, BC |
| Sat Aug 22 | at St. Louis | 5:30 PM | 8-8-18 | 32 PTS | Energizer Park · St. Louis, MO |
| Sat Aug 29 | vs San Jose | 5:30 PM | 11-8-15 | 41 PTS | Shell Energy Stadium · Houston, TX |
| Sat Sep 5 | at Charlotte | 4:30 PM | 19-2-13 | 59 PTS | Bank of America Stadium · Charlotte, NC |
| Wed Sep 9 | vsSalt Lake | 5:30 PM | 12-5-17 | 41 PTS | Shell Energy Stadium · Houston, TX |
| Sat Sep 12 | atSan Jose | 7:30 PM | 11-8-15 | 41 PTS | PayPal Park · San Jose, CA |
| Sat Sep 19 | vs Cincinnati | 5:30 PM | 20-5-9 | 65 PTS | Shell Energy Stadium · Houston, TX |
| Sat Sep 26 | vsKansas City | 5:30 PM | 7-7-20 | 28 PTS | Shell Energy Stadium · Houston, TX |
| Sat Oct 10 | at Minnesota | 5:30 PM | 16-10-8 | 58 PTS | Allianz Field · Saint Paul, MN |
| Wed Oct 14 | atSan Diego | 7:30 PM | 19-6-9 | 63 PTS | Snapdragon Stadium · San Diego, CA |
| Sat Oct 17 | vsDallas | 5:30 PM | 11-11-12 | 44 PTS | Shell Energy Stadium · Houston, TX |
| Sat Oct 24 | vsMinnesota | 5:30 PM | 16-10-8 | 58 PTS | Shell Energy Stadium · Houston, TX |
| Wed Oct 28 | atSeattle | 7:30 PM | 15-10-9 | 55 PTS | Lumen Field · Seattle, WA |
| Sun Nov 1 | atPortland | 5:00 PM | 11-11-12 | 44 PTS | Providence Park · Portland, OR |
| Sat Nov 7 | vsSt. Louis | 4:00 PM | 8-8-18 | 32 PTS | Shell Energy Stadium · Houston, TX |
