| 1 | Mon Apr 6 | at D-backs | W5-4 | 1-0 | 1.000 | Chase Field · Phoenix, AZ |
| 2 | Tue Apr 7 | at D-backs | L6-7 | 1-1 | .500 | Chase Field · Phoenix, AZ |
| 3 | Wed Apr 8 | at D-backs | W5-2 | 2-1 | .667 | Chase Field · Phoenix, AZ |
| 4 | Thu Apr 9 | at Padres | W1-0 (12) | 3-1 | .750 | Petco Park · San Diego, CA |
| 5 | Fri Apr 10 | at Padres | L0-1 | 3-2 | .600 | Petco Park · San Diego, CA |
| 6 | Sat Apr 11 | at Padres | L2-10 | 3-3 | .500 | Petco Park · San Diego, CA |
| 7 | Sun Apr 12 | at Padres | L4-6 | 3-4 | .429 | Petco Park · San Diego, CA |
| 8 | Mon Apr 13 | vs Rockies | L0-2 | 3-5 | .375 | Oracle Park · San Francisco, CA |
| 9 | Tue Apr 14 | vs Rockies | L1-4 | 3-6 | .333 | Oracle Park · San Francisco, CA |
| 10 | Wed Apr 15 | vs Rockies | L2-4 | 3-7 | .300 | Oracle Park · San Francisco, CA |
| 11 | Thu Apr 16 | vs D-backs | L6-7 (12) | 3-8 | .273 | Oracle Park · San Francisco, CA |
| 12 | Fri Apr 17 | vs D-backs | L0-9 | 3-9 | .250 | Oracle Park · San Francisco, CA |
| 13 | Sat Apr 18 | vs D-backs | W4-1 | 4-9 | .308 | Oracle Park · San Francisco, CA |
| 14 | Sun Apr 19 | vs D-backs | L1-5 | 4-10 | .286 | Oracle Park · San Francisco, CA |
| 15 | Tue Apr 21 | vs Dodgers | W6-2 | 5-10 | .333 | Oracle Park · San Francisco, CA |
| 16 | Wed Apr 22 | vs Dodgers | W3-2 | 6-10 | .375 | Oracle Park · San Francisco, CA |
| 17 | Thu Apr 23 | vs Dodgers | W3-2 (10) | 7-10 | .412 | Oracle Park · San Francisco, CA |
| 18 | Fri Apr 24 | at Rockies | L4-6 | 7-11 | .389 | Coors Field · Denver, CO |
| 19 | Sat Apr 25 | at Rockies | W5-4 (11) | 8-11 | .421 | Coors Field · Denver, CO |
| 20 | Mon Apr 27 | at Dodgers | L3-8 | 8-12 | .400 | Dodger Stadium · Los Angeles, CA |
| 21 | Tue Apr 28 | at Dodgers | W2-1 | 9-12 | .429 | Dodger Stadium · Los Angeles, CA |
| 22 | Wed Apr 29 | at Dodgers | L3-7 | 9-13 | .409 | Dodger Stadium · Los Angeles, CA |
| 23 | Fri May 1 | vs Angels | W3-2 | 10-13 | .435 | Oracle Park · San Francisco, CA |
| 24 | Sat May 2 | vs Angels | W5-4 | 11-13 | .458 | Oracle Park · San Francisco, CA |
| 25 | Sun May 3 | vs Angels | W5-0 | 12-13 | .480 | Oracle Park · San Francisco, CA |
| 26 | Mon May 4 | vs Padres | W2-0 | 13-13 | .500 | Oracle Park · San Francisco, CA |
| 27 | Tue May 5 | vs Padres | W6-0 | 14-13 | .519 | Oracle Park · San Francisco, CA |
| 28 | Wed May 6 | vs Padres | L1-9 | 14-14 | .500 | Oracle Park · San Francisco, CA |
| 29 | Thu May 7 | vs Marlins | L2-7 | 14-15 | .483 | Oracle Park · San Francisco, CA |
| 30 | Fri May 8 | vs Marlins | W6-0 | 15-15 | .500 | Oracle Park · San Francisco, CA |
| 31 | Sat May 9 | vs Marlins | L2-6 | 15-16 | .484 | Oracle Park · San Francisco, CA |
| 32 | Sun May 10 | vs Marlins | W3-2 | 16-16 | .500 | Oracle Park · San Francisco, CA |
| 33 | Tue May 12 | at Astros | W8-1 | 17-16 | .515 | Minute Maid Park · Houston, TX |
| 34 | Wed May 13 | at Astros | L3-4 | 17-17 | .500 | Minute Maid Park · Houston, TX |
| 35 | Thu May 14 | at Reds | L3-4 | 17-18 | .486 | Great American Ball Park · Cincinnati, OH |
| 36 | Fri May 15 | at Reds | W10-2 | 18-18 | .500 | Great American Ball Park · Cincinnati, OH |
| 37 | Sat May 16 | at Reds | W11-2 | 19-18 | .514 | Great American Ball Park · Cincinnati, OH |
| 38 | Sun May 17 | at Reds | W9-8 | 20-18 | .526 | Great American Ball Park · Cincinnati, OH |
| 39 | Tue May 19 | vs Dodgers | W2-0 | 21-18 | .538 | Oracle Park · San Francisco, CA |
| 40 | Wed May 20 | vs Dodgers | W4-0 | 22-18 | .550 | Oracle Park · San Francisco, CA |
| 41 | Thu May 21 | vs Dodgers | W4-0 | 23-18 | .561 | Oracle Park · San Francisco, CA |
| 42 | Fri May 22 | at Rockies | W11-8 | 24-18 | .571 | Coors Field · Denver, CO |
| 43 | Sat May 23 | at Rockies | W10-8 | 25-18 | .581 | Coors Field · Denver, CO |
| 44 | Sat May 23 | at Rockies | L3-5 | 25-19 | .568 | Coors Field · Denver, CO |
| 45 | Sun May 24 | at Rockies | L2-11 | 25-20 | .556 | Coors Field · Denver, CO |
| 46 | Mon May 25 | at Brewers | W8-4 | 26-20 | .565 | American Family Field · Milwaukee, WI |
| 47 | Tue May 26 | at Brewers | W6-3 | 27-20 | .574 | American Family Field · Milwaukee, WI |
| 48 | Wed May 27 | at Brewers | W3-1 | 28-20 | .583 | American Family Field · Milwaukee, WI |
| 49 | Thu May 28 | vs Braves | W7-0 | 29-20 | .592 | Oracle Park · San Francisco, CA |
| 50 | Fri May 29 | vs Braves | W4-2 | 30-20 | .600 | Oracle Park · San Francisco, CA |
| 51 | Sat May 30 | vs Braves | L0-8 | 30-21 | .588 | Oracle Park · San Francisco, CA |
| 52 | Sun May 31 | vs Braves | L5-7 | 30-22 | .577 | Oracle Park · San Francisco, CA |
| 53 | Mon Jun 1 | vs Pirates | L3-4 | 30-23 | .566 | Oracle Park · San Francisco, CA |
| 54 | Tue Jun 2 | vs Pirates | L4-7 | 30-24 | .556 | Oracle Park · San Francisco, CA |
| 55 | Wed Jun 3 | vs Pirates | L2-5 | 30-25 | .545 | Oracle Park · San Francisco, CA |
| 56 | Fri Jun 5 | at Phillies | W5-4 | 31-25 | .554 | Citizens Bank Park · Philadelphi, PA |
| 57 | Sat Jun 6 | at Phillies | W7-5 | 32-25 | .561 | Citizens Bank Park · Philadelphi, PA |
| 58 | Sun Jun 7 | at Phillies | L4-6 | 32-26 | .552 | Citizens Bank Park · Philadelphi, PA |
| 59 | Tue Jun 9 | at Mets | W5-0 | 33-26 | .559 | Citi Field · Queens, NY |
| 60 | Wed Jun 10 | at Mets | W8-5 | 34-26 | .567 | Citi Field · Queens, NY |
| 61 | Thu Jun 11 | at Mets | L4-5 | 34-27 | .557 | Citi Field · Queens, NY |
| 62 | Fri Jun 12 | vs D-backs | L0-1 | 34-28 | .548 | Oracle Park · San Francisco, CA |
| 63 | Sat Jun 13 | vs D-backs | L2-4 | 34-29 | .540 | Oracle Park · San Francisco, CA |
| 64 | Sun Jun 14 | vs D-backs | L0-4 | 34-30 | .531 | Oracle Park · San Francisco, CA |
| 65 | Mon Jun 15 | vs Mariners | L1-5 | 34-31 | .523 | Oracle Park · San Francisco, CA |
| 66 | Tue Jun 16 | vs Mariners | W6-2 | 35-31 | .530 | Oracle Park · San Francisco, CA |
| 67 | Wed Jun 17 | at Mariners | L0-2 | 35-32 | .522 | T-Mobile Park · Seattle, WA |
| 68 | Thu Jun 18 | at Mariners | W7-0 | 36-32 | .529 | T-Mobile Park · Seattle, WA |
| 69 | Fri Jun 19 | at Dodgers | W9-5 | 37-32 | .536 | Dodger Stadium · Los Angeles, CA |
| 70 | Sat Jun 20 | at Dodgers | W6-2 | 38-32 | .543 | Dodger Stadium · Los Angeles, CA |
| 71 | Sun Jun 21 | at Dodgers | L2-10 | 38-33 | .535 | Dodger Stadium · Los Angeles, CA |
| 72 | Tue Jun 23 | vs Padres | L2-3 (11) | 38-34 | .528 | Oracle Park · San Francisco, CA |
| 73 | Wed Jun 24 | vs Padres | W6-0 | 39-34 | .534 | Oracle Park · San Francisco, CA |
| 74 | Thu Jun 25 | vs Padres | W13-8 | 40-34 | .541 | Oracle Park · San Francisco, CA |
| 75 | Fri Jun 26 | vs Rockies | L6-8 | 40-35 | .533 | Oracle Park · San Francisco, CA |
| 76 | Sat Jun 27 | vs Rockies | W7-5 | 41-35 | .539 | Oracle Park · San Francisco, CA |
| 77 | Sun Jun 28 | vs Rockies | W6-3 | 42-35 | .545 | Oracle Park · San Francisco, CA |
| 78 | Tue Jun 30 | at Marlins | L3-5 | 42-36 | .538 | LoanDepot Park · Miami, FL |
| 79 | Wed Jul 1 | at Marlins | L5-6 | 42-37 | .532 | LoanDepot Park · Miami, FL |
| 80 | Thu Jul 2 | at Marlins | L4-5 | 42-38 | .525 | LoanDepot Park · Miami, FL |
| 81 | Fri Jul 3 | at Nationals | L1-2 | 42-39 | .519 | Nationals Park · Washington, D.C. |
| 82 | Sat Jul 4 | at Nationals | L3-9 | 42-40 | .512 | Nationals Park · Washington, D.C. |
| 83 | Sun Jul 5 | at Nationals | L1-3 | 42-41 | .506 | Nationals Park · Washington, D.C. |
| 84 | Mon Jul 6 | vs Mets | L0-3 | 42-42 | .500 | Oracle Park · San Francisco, CA |
| 85 | Tue Jul 7 | vs Mets | W3-0 | 43-42 | .506 | Oracle Park · San Francisco, CA |
| 86 | Wed Jul 8 | vs Mets | L1-4 | 43-43 | .500 | Oracle Park · San Francisco, CA |
| 87 | Fri Jul 10 | vs Phillies | W15-2 | 44-43 | .506 | Oracle Park · San Francisco, CA |
| 88 | Sat Jul 11 | vs Phillies | W8-5 | 45-43 | .511 | Oracle Park · San Francisco, CA |
| 89 | Sun Jul 12 | vs Phillies | W4-2 | 46-43 | .517 | Oracle Park · San Francisco, CA |
| 90 | Fri Jul 17 | at D-backs | W6-5 (12) | 47-43 | .522 | Chase Field · Phoenix, AZ |
| 91 | Sat Jul 18 | at D-backs | W8-4 | 48-43 | .527 | Chase Field · Phoenix, AZ |
| 92 | Sun Jul 19 | at D-backs | W2-1 | 49-43 | .533 | Chase Field · Phoenix, AZ |
| 93 | Mon Jul 20 | at Padres | L2-4 | 49-44 | .527 | Petco Park · San Diego, CA |
| 94 | Tue Jul 21 | at Padres | W9-3 | 50-44 | .532 | Petco Park · San Diego, CA |
| 95 | Wed Jul 22 | at Padres | W7-1 | 51-44 | .537 | Petco Park · San Diego, CA |
| 96 | Fri Jul 24 | vs Athletics | W9-3 | 52-44 | .542 | Oracle Park · San Francisco, CA |
| 97 | Sat Jul 25 | vs Athletics | W2-1 | 53-44 | .546 | Oracle Park · San Francisco, CA |
| 98 | Sun Jul 26 | vs Athletics | W4-3 | 54-44 | .551 | Oracle Park · San Francisco, CA |
| 99 | Mon Jul 27 | vs Brewers | W4-2 | 55-44 | .556 | Oracle Park · San Francisco, CA |
| 100 | Tue Jul 28 | vs Brewers | L2-5 | 55-45 | .550 | Oracle Park · San Francisco, CA |
| 101 | Wed Jul 29 | vs Brewers | W5-0 | 56-45 | .554 | Oracle Park · San Francisco, CA |
| 102 | Fri Jul 31 | at Rangers | L3-6 | 56-46 | .549 | Globe Life Field · Arlington, TX |
| 103 | Sat Aug 1 | at Rangers | W9-7 (11) | 57-46 | .553 | Globe Life Field · Arlington, TX |
| 104 | Sun Aug 2 | at Rangers | L1-2 | 57-47 | .548 | Globe Life Field · Arlington, TX |
| 105 | Mon Aug 3 | at Braves | L8-9 (12) | 57-48 | .543 | Truist Park · Cumberland, GA |
| 106 | Tue Aug 4 | at Braves | W8-3 | 58-48 | .547 | Truist Park · Cumberland, GA |
| 107 | Wed Aug 5 | at Braves | W6-1 | 59-48 | .551 | Truist Park · Cumberland, GA |
| 108 | Thu Aug 6 | at Cubs | L4-5 | 59-49 | .546 | Wrigley Field · Chicago, IL |
| 109 | Fri Aug 7 | at Cubs | L3-7 | 59-50 | .541 | Wrigley Field · Chicago, IL |
| 110 | Sat Aug 8 | at Cubs | L6-8 | 59-51 | .536 | Wrigley Field · Chicago, IL |
| 111 | Sun Aug 9 | at Cubs | L0-2 | 59-52 | .532 | Wrigley Field · Chicago, IL |
| 112 | Tue Aug 11 | vs Astros | W3-1 | 60-52 | .536 | Oracle Park · San Francisco, CA |
| 113 | Wed Aug 12 | vs Astros | L0-2 | 60-53 | .531 | Oracle Park · San Francisco, CA |
| 114 | Thu Aug 13 | vs Nationals | W3-1 | 61-53 | .535 | Oracle Park · San Francisco, CA |
| 115 | Fri Aug 14 | vs Nationals | W8-5 | 62-53 | .539 | Oracle Park · San Francisco, CA |
| 116 | Sat Aug 15 | vs Nationals | W12-6 | 63-53 | .543 | Oracle Park · San Francisco, CA |
| 117 | Sun Aug 16 | vs Nationals | W5-0 | 64-53 | .547 | Oracle Park · San Francisco, CA |
| 118 | Mon Aug 17 | at Cardinals | L1-2 | 64-54 | .542 | Busch Stadium · St. Louis, MO |
| 119 | Tue Aug 18 | at Cardinals | W2-0 | 65-54 | .546 | Busch Stadium · St. Louis, MO |
| 120 | Wed Aug 19 | at Cardinals | L3-4 | 65-55 | .542 | Busch Stadium · St. Louis, MO |
| 121 | Thu Aug 20 | at Pirates | L0-4 | 65-56 | .537 | PNC Park · Pittsburgh, PA |
| 122 | Fri Aug 21 | at Pirates | W6-4 | 66-56 | .541 | PNC Park · Pittsburgh, PA |
| 123 | Sat Aug 22 | at Pirates | L2-3 | 66-57 | .537 | PNC Park · Pittsburgh, PA |
| 124 | Sun Aug 23 | at Pirates | L2-5 | 66-58 | .532 | PNC Park · Pittsburgh, PA |
| 125 | Tue Aug 25 | vs Cubs | L5-8 | 66-59 | .528 | Oracle Park · San Francisco, CA |
| 126 | Wed Aug 26 | vs Cubs | W4-2 | 67-59 | .532 | Oracle Park · San Francisco, CA |
| 127 | Thu Aug 27 | vs Cubs | W9-1 | 68-59 | .535 | Oracle Park · San Francisco, CA |
| 128 | Fri Aug 28 | vs Cardinals | W5-4 | 69-59 | .539 | Oracle Park · San Francisco, CA |
| 129 | Sat Aug 29 | vs Cardinals | L0-6 | 69-60 | .535 | Oracle Park · San Francisco, CA |
| 130 | Sun Aug 30 | vs Cardinals | L5-7 | 69-61 | .531 | Oracle Park · San Francisco, CA |
| 131 | Mon Aug 31 | at Dodgers | L4-5 (14) | 69-62 | .527 | Dodger Stadium · Los Angeles, CA |
| 132 | Tue Sep 1 | at Dodgers | L1-2 | 69-63 | .523 | Dodger Stadium · Los Angeles, CA |
| 133 | Wed Sep 2 | at Dodgers | L1-2 | 69-64 | .519 | Dodger Stadium · Los Angeles, CA |
| 134 | Thu Sep 3 | at Rockies | L3-11 | 69-65 | .515 | Coors Field · Denver, CO |
| 135 | Fri Sep 4 | at Rockies | L1-2 | 69-66 | .511 | Coors Field · Denver, CO |
| 136 | Sat Sep 5 | at Rockies | W7-3 | 70-66 | .515 | Coors Field · Denver, CO |
| 137 | Sun Sep 6 | at Rockies | W7-4 | 71-66 | .518 | Coors Field · Denver, CO |
| 138 | Mon Sep 7 | at D-backs | L1-6 | 71-67 | .514 | Chase Field · Phoenix, AZ |
| 139 | Tue Sep 8 | at D-backs | W6-2 | 72-67 | .518 | Chase Field · Phoenix, AZ |
| 140 | Wed Sep 9 | at D-backs | L1-2 | 72-68 | .514 | Chase Field · Phoenix, AZ |
| 141 | Fri Sep 11 | vs Padres | W9-1 | 73-68 | .518 | Oracle Park · San Francisco, CA |
| 142 | Sat Sep 12 | vs Padres | W8-0 | 74-68 | .521 | Oracle Park · San Francisco, CA |
| 143 | Sun Sep 13 | vs Padres | W10-3 | 75-68 | .524 | Oracle Park · San Francisco, CA |
| 144 | Mon Sep 14 | vs Reds | W5-3 | 76-68 | .528 | Oracle Park · San Francisco, CA |
| 145 | Tue Sep 15 | vs Reds | L8-9 (10) | 76-69 | .524 | Oracle Park · San Francisco, CA |
| 146 | Wed Sep 16 | vs Reds | W5-3 | 77-69 | .527 | Oracle Park · San Francisco, CA |
| 147 | Fri Sep 18 | vs D-backs | L0-2 | 77-70 | .524 | Oracle Park · San Francisco, CA |
| 148 | Sat Sep 19 | vs D-backs | L0-6 | 77-71 | .520 | Oracle Park · San Francisco, CA |
| 149 | Sun Sep 20 | vs D-backs | W5-1 | 78-71 | .523 | Oracle Park · San Francisco, CA |
| 150 | Tue Sep 22 | at Padres | W4-2 | 79-71 | .527 | Petco Park · San Diego, CA |
| 151 | Wed Sep 23 | at Padres | L4-5 | 79-72 | .523 | Petco Park · San Diego, CA |
| 152 | Thu Sep 24 | at Padres | L4-5 | 79-73 | .520 | Petco Park · San Diego, CA |
| 153 | Fri Sep 25 | at Athletics | L4-5 | 79-74 | .516 | RingCentral Coliseum · Oakland, CA |
| 154 | Sat Sep 26 | at Athletics | W14-10 | 80-74 | .519 | RingCentral Coliseum · Oakland, CA |
| 155 | Sun Sep 27 | at Athletics | W5-4 | 81-74 | .523 | RingCentral Coliseum · Oakland, CA |
| 156 | Mon Sep 28 | vs Dodgers | W3-2 (12) | 82-74 | .526 | Oracle Park · San Francisco, CA |
| 157 | Tue Sep 29 | vs Dodgers | L0-8 | 82-75 | .522 | Oracle Park · San Francisco, CA |
| 158 | Wed Sep 30 | vs Dodgers | W5-0 | 83-75 | .525 | Oracle Park · San Francisco, CA |
| 159 | Thu Oct 1 | vs Dodgers | L2-3 | 83-76 | .522 | Oracle Park · San Francisco, CA |
| 160 | Fri Oct 2 | vs Rockies | L3-9 | 83-77 | .519 | Oracle Park · San Francisco, CA |
| 161 | Sat Oct 3 | vs Rockies | W3-2 | 84-77 | .522 | Oracle Park · San Francisco, CA |
| 162 | Sun Oct 4 | vs Rockies | L3-7 | 84-78 | .519 | Oracle Park · San Francisco, CA |